Introduction of the energy to break an avalanche as a promising parameter for powder flowability prediction

dc.accessRightsAnonymous*
dc.audienceScienceen_US
dc.contributor.authorTrpělková, Žofie
dc.contributor.authorKuentz, Martin
dc.date.accessioned2021-05-10T06:50:34Z
dc.date.available2021-05-10T06:50:34Z
dc.date.issued2020-09-20
dc.description.abstractDynamic avalanche testing is a newer method useful even with cohesive powder samples. To evaluate flow properties of pharmaceutical powder excipients, break energy (BE) is introduced as a new promising avalanche parameter. Conventional pharmacopoeial methods and an annular shear cell were utilized to characterize 23 pharmaceutical powder samples including binary mixtures. Subsequently, rotating drum avalanching was studied to better understand behaviour of powders. A good linear regression between the energy to break a powder avalanche and powder cohesion with R2 = 0.823 was detected. The relationship between BE and the flow function value, estimated by shear testing, allowed to identify two samples with excellent flow functions: Cellets 100 and Neusilin US2. The latter sample also had very low BE although the mass flow rate was the poorest observed out of 23 samples. Therefore, the BE from avalanching testing seems to be a sensitive measure of cohesion and flow function behaviour.en_US
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S0032591020307191en_US
dc.identifier.doi10.1016/j.powtec.2020.07.095
dc.identifier.issn0032-5910
dc.identifier.issn1873-328X
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/32418
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofPowder Technologyen_US
dc.titleIntroduction of the energy to break an avalanche as a promising parameter for powder flowability predictionen_US
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dc.volume375en_US
dspace.entity.typePublication
fhnw.InventedHereYesen_US
fhnw.IsStudentsWorknoen_US
fhnw.PublishedSwitzerlandYesen_US
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publicationen_US
fhnw.affiliation.hochschuleHochschule für Life Sciencesde_CH
fhnw.affiliation.institutInstitut für Pharma Technologyde_CH
fhnw.pagination33-41en_US
fhnw.publicationOnlineJaen_US
fhnw.publicationStatePublisheden_US
relation.isAuthorOfPublication68819448-8611-488b-87bc-1b1cf9a6a1b4
relation.isAuthorOfPublication.latestForDiscovery68819448-8611-488b-87bc-1b1cf9a6a1b4
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