Intraoperative acceleration measurements to quantify tremor during deep brain stimulation surgery
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Authors
Coste, Jérôme
Lemaire, Jean-Jaques
Taub, Ethan
Schüpbach, W.M. Michael
Pollo, Claudio
Guzman, Raphael
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Publication date
2016
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01A - Journal article
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Parent work
Medical & Biological Engineering & Computing
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Issue / Number
Pages / Duration
1-14
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Publisher / Publishing institution
Springer
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Abstract
Deep brain stimulation (DBS) surgery is extensively used in the treatment of movement disorders. Nevertheless, methods to evaluate the clinical response during intraoperative stimulation tests to identify the optimal position for the implantation of the chronic DBS lead remain subjective. In this paper, we describe a new, versatile method for quantitative intraoperative evaluation of improvement in tremor with an acceleration sensor that is mounted on the patient’s wrist during surgery. At each anatomical test position, the improvement in tremor compared to the initial tremor is estimated on the basis of extracted outcome measures. This method was tested on 15 tremor patients undergoing DBS surgery in two centers. Data from 359 stimulation tests were acquired. Our results suggest that accelerometric evaluation detects tremor changes more sensitively than subjective visual ratings. The effective stimulation current amplitudes identified from the quantitative data (1.1 ± 0.8 mA) are lower than those identified by visual evaluation (1.7 ± 0.8 mA) for similar improvement in tremor. Additionally, if these data had been used to choose the chronic implant position of the DBS lead, 15 of the 26 choices would have been different. These results show that our method of accelerometric evaluation can potentially improve DBS targeting.
Keywords
Deep brain stimulation, Intraoperative monitoring, Essential tremor, Acceleration, Tremor, Parkinson’s disease
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0140-0118
1741-0444
1741-0444
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
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Peer review of the complete publication
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Citation
SHAH, Ashesh, Jérôme COSTE, Jean-Jaques LEMAIRE, Ethan TAUB, W.M. Michael SCHÜPBACH, Claudio POLLO, Erik SCHKOMMODAU, Raphael GUZMAN und Simone HEMM-ODE, 2016. Intraoperative acceleration measurements to quantify tremor during deep brain stimulation surgery. Medical & Biological Engineering & Computing. 2016. S. 1–14. DOI 10.1007/s11517-016-1559-9. Verfügbar unter: http://hdl.handle.net/11654/23575