Exploration of solubilisation effects facilitated by the combination of Soluplus® with ionic surfactants
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Author (Corporation)
Publication date
01.02.2025
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Type
01A - Journal article
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Parent work
European Journal of Pharmaceutical Sciences
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Series number
Volume
205
Issue / Number
Pages / Duration
106957
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Publisher / Publishing institution
Elsevier
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Abstract
Preclinical testing of new drug candidates frequently necessitates high-dose solution formulations to support robust testing in rodent models. This study aimed to expand the range of high solubilisation capacity formulations by exploring the solubilisation effects of the polymeric surfactant Soluplus® in combination with ionic surfactants. The interactions between Soluplus® and three ionic surfactants, sodium dodecyl sulphate, dioctyl sodium succinate, and sodium oleate, with a primary focus on solubility enhancement were investigated over a range of ionic surfactant concentrations. The solubilisation profiles for seven model drugs were obtained, and the vehicles were characterised by their visual characteristics, dynamic light scattering, and viscosity measurements. The solubilisation profiles were non-linear, indicating the formation of different colloidal species with individual solubilisation strengths depending on surfactant type and concentration, demonstrating substantial solubility enhancement. For certain drugs more than additive solubilisation, facilitated by synergistic interactions between Soluplus® and the ionic surfactants, was obtained. Overall, the solubility increase provided by the excipient combinations resulted in non-linear and drug specific solubilisation profiles. The non-linearities observed were reflected in visual observations of the vehicles appearance, DLS and viscosity measurements, which collectively indicated a change in polymer aggregation with increasing concentration of anionic surfactant. This investigation highlights that already low quantities of ionic surfactants introduced to Soluplus® may substantially enhance solubility, which offers a promising approach for further exploration in preclinical drug development where more conventional solubilising formulation strategies may fall short.
Keywords
Soluplus®, Colloids, Surfactants, Preclinical formulations, Solubilisation, Micelles
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ISBN
ISSN
0928-0987
1879-0720
1879-0720
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Gold
License
Citation
Lange, J. J., Enzner, L., Kuentz, M., O’Dwyer, P. J., Saal, W., Griffin, B. T., & Wyttenbach, N. (2025). Exploration of solubilisation effects facilitated by the combination of Soluplus® with ionic surfactants. European Journal of Pharmaceutical Sciences, 205, 106957. https://doi.org/10.1016/j.ejps.2024.106957