Selective grignard addition to dialkyl oxalates: A flow chemistry approach
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Authors
Author (Corporation)
Publication date
2025
Typ of student thesis
Master
Course of study
Chemical Engineering
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11 - Student thesis
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Hochschule für Life Sciences FHNW
Place of publication / Event location
Muttenz
Edition
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Assignee
Practice partner / Client
Bayer CropScience Schweiz AG
Abstract
During the production of an intermediate of a major product of Bayer CropScience Schweiz AG in Muttenz, Switzerland, a side compound is formed that lowers yield and removal requires intensive workup. In the reaction the Grignard reagent 2 reacts with dialkyl oxalate 3 to an α-keto ester 3 (Fig. 1). Currently a semi-batch operation mode is used (Fig. 2). Fig. 1 and 2: Simplified synthesis of desired compound 3 and formation of undesired side compound 4 and current batch process. A second addition (overreaction) of the Grignard reagent 2 to compound 3 can occur and the undesired side compound 4 is formed. The following potentials have been identified:
- Increasing the yield would enhance the overall efficiency of the process.
- Reduction of bis-alcohol (4) would be desirable for both, economic and environmental impact.
- An optimized and simplified process would lead to more flexibility in the production plant of Bayer CropScience Schweiz AG in Muttenz.
Keywords
Flow chemistry, Continuous processes, Process development, Grignard
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Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
New Work
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Review
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Citation
Moschen, L. (2025). Selective grignard addition to dialkyl oxalates: A flow chemistry approach [Hochschule für Life Sciences FHNW]. https://doi.org/10.26041/fhnw-12995