Lattice Microarchitecture for Bone Tissue Engineering from Calcium Phosphate Compared to Titanium
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Authors
Chen, Tse-Hsiang
Ghayor, Chafik
Siegenthaler, Barbara
Rüegg, Jasmine
Weber, Franz E.
Author (Corporation)
Publication date
10.2018
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01A - Journal article
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Supervisor
Parent work
Tissue Engineering. Part A
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Volume
24
Issue / Number
19-20
Pages / Duration
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Publisher / Publishing institution
Mary Ann Liebert
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Abstract
Additive manufacturing of bone tissue engineering scaffolds will become a key element for personalized bone tissue engineering in the near future. Several additive manufacturing processes are based on extrusion where the deposition of the filament will result in a three-dimensional lattice structure. Recently, we studied diverse lattice structures for bone tissue engineering realized by laser sintering of titanium. In this work, we used lithography-based ceramic manufacturing of lattice structures to produce scaffolds from tricalcium phosphates (TCP) and compared them in vivo to congruent titanium scaffolds manufactured with the identical computer-aided design data to look for material-based differences in bony healing. The results show that, during a 4-week period in a noncritical-size defect in a rabbit calvarium, both scaffolds with the identical microarchitecture performed equally well in terms of bony regeneration and bony bridging of the defect. A significant increase in both parameters could only be achieved when the TCP-based scaffolds were doped with bone morphogenetic protein-2. In a critical-size defect in the calvarial bone of rabbits, however, the titanium scaffold performed significantly better than the TCP-based scaffold, most likely due to its higher mechanical stability. We conclude that titanium and TCP-based scaffolds of the same microarchitecture perform equally well in terms of bone regeneration, provided the microarchitecture meets the mechanical demand at the site of implantation.
Keywords
additive manufacturing, bone regeneration, bone repair, calcium phosphate, lattice architecture, litography, osteoconduction, titanium
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ISBN
ISSN
1937-335X
1937-3341
1937-3341
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
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License
Citation
Chen, T.-H., Ghayor, C., Siegenthaler, B., Schuler, F., Rüegg, J., de Wild, M., & Weber, F. E. (2018). Lattice Microarchitecture for Bone Tissue Engineering from Calcium Phosphate Compared to Titanium. Tissue Engineering. Part A, 24(19-20). https://doi.org/10.1089/ten.TEA.2018.0014