A review of the clinical introduction of 4D particle therapy research concepts
Author (Corporation)
Publication date
01/2024
Typ of student thesis
Course of study
Type
01A - Journal article
Editors
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Parent work
Physics and Imaging in Radiation Oncology
Special issue
DOI of the original publication
Link
Series
Series number
Volume
29
Issue / Number
Pages / Duration
100535
Patent number
Publisher / Publishing institution
Elsevier
Place of publication / Event location
Edition
Version
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Practice partner / Client
Abstract
Background and purpose: Many 4D particle therapy research concepts have been recently translated into clinics, however, remaining substantial differences depend on the indication and institute-related aspects. This work aims to summarise current state-of-the-art 4D particle therapy technology and outline a roadmap for future research and developments.
Material and methods: This review focused on the clinical implementation of 4D approaches for imaging, treatment planning, delivery and evaluation based on the 2021 and 2022 4D Treatment Workshops for Particle Therapy as well as a review of the most recent surveys, guidelines and scientific papers dedicated to this topic.
Results: Available technological capabilities for motion surveillance and compensation determined the course of each 4D particle treatment. 4D motion management, delivery techniques and strategies including imaging were diverse and depended on many factors. These included aspects of motion amplitude, tumour location, as well as accelerator technology driving the necessity of centre-specific dosimetric validation. Novel methodologies for X-ray based image processing and MRI for real-time tumour tracking and motion management were shown to have a large potential for online and offline adaptation schemes compensating for potential anatomical changes over the treatment course. The latest research developments were dominated by particle imaging, artificial intelligence methods and FLASH adding another level of complexity but also opportunities in the context of 4D treatments.
Conclusion: This review showed that the rapid technological advances in radiation oncology together with the available intrafractional motion management and adaptive strategies paved the way towards clinical implementation.
Keywords
Subject (DDC)
600 - Technik, Medizin, angewandte Wissenschaften
Event
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ISBN
ISSN
2405-6316
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Gold
Citation
KNÄUSL, Barbara, Gabriele BELOTTI, Jenny BERTHOLET, Juliane DAARTZ, Stella FLAMPOURI, Mischa HOOGEMAN, Antje KNOPF, Haibo LIN, Astrid MOERMAN, Chiara PAGANELLI, Antoni RUCINSKI, Reinhard SCHULTE, Shing SHIMIZU, Kristin STÜTZER, Xiaodong ZHANG, Ye ZHANG und Katarzyna CZERSKA, 2024. A review of the clinical introduction of 4D particle therapy research concepts. Physics and Imaging in Radiation Oncology. Januar 2024. Bd. 29, S. 100535. DOI 10.1016/j.phro.2024.100535. Verfügbar unter: https://doi.org/10.26041/fhnw-11788