Amorphous solid dispersion of a binary formulation with felodipine and HPMC for 3D printed floating tablets
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Author (Corporation)
Publication date
06/2024
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01A - Journal article
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Parent work
International Journal of Pharmaceutics
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Volume
658
Issue / Number
Pages / Duration
124215
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Elsevier
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Abstract
This study focuses on the combination of three-dimensional printing (3DP) and amorphous solid dispersion (ASD) technologies for the manufacturing of gastroretentive floating tablets. Employing hot melt extrusion (HME) and fused deposition modeling (FDM), the study investigates the development of drug-loaded filaments and 3D printed (3DP) tablets containing felodipine as model drug and hydroxypropyl methylcellulose (HPMC) as the polymeric carrier. Prior to fabrication, solubility parameter estimation and molecular dynamics simulations were applied to predict drug-polymer interactions, which are crucial for ASD formation. Physical bulk and surface characterization complemented the quality control of both drug-loaded filaments and 3DP tablets. The analysis confirmed a successful amorphous dispersion of felodipine within the polymeric matrix. Furthermore, the low infill percentage and enclosed design of the 3DP tablet allowed for obtaining low-density systems. This structure resulted in buoyancy during the entire drug release process until a complete dissolution of the 3DP tablets (more than 8 h) was attained. The particular design made it possible for a single polymer to achieve a zero-order controlled release of the drug, which is considered the ideal kinetics for a gastroretentive system. Accordingly, this study can be seen as an advancement in ASD formulation for 3DP technology within pharmaceutics.
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ISBN
ISSN
0378-5173
1873-3476
1873-3476
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Hybrid
Citation
Mora-Castaño, G., Millán-Jiménez, M., Niederquell, A., Schönenberger, M., Shojaie, F., Kuentz, M., & Caraballo, I. (2024). Amorphous solid dispersion of a binary formulation with felodipine and HPMC for 3D printed floating tablets. International Journal of Pharmaceutics, 658, 124215. https://doi.org/10.1016/j.ijpharm.2024.124215