Comparative drug solubility studies using shake-flask versus a laser-based robotic method
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Autor:innen
Rahimpour, Elaheh
Moradi, Milad
Sheikhi-Sovari, Atefeh
Rezaei, Homa
Rezaei, Hadis
Jouyban-Gharamaleki, Vahid
Jouyban, Abolghasem
Autor:in (Körperschaft)
Publikationsdatum
2023
Typ der Arbeit
Studiengang
Sammlung
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
AAPS PharmSciTech
Themenheft
DOI der Originalpublikation
Link
Reihe / Serie
Reihennummer
Jahrgang / Band
24
Ausgabe / Nummer
7
Seiten / Dauer
Patentnummer
Verlag / Herausgebende Institution
Springer
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
Drug solubility is of central importance to the pharmaceutical sciences, but reported values often show discrepancies. Various factors have been discussed in the literature to account for such differences, but the influence of manual testing in comparison to a robotic system has not been studied adequately before. In this study, four expert researchers were asked to measure the solubility of four drugs with various solubility behaviors (i.e., paracetamol, mesalazine, lamotrigine, and ketoconazole) in the same laboratory with the same instruments, method, and material sources and repeated their measurements after a time interval. In addition, the same solubility data were determined using an automated laser-based setup. The results suggest that manual testing leads to a handling influence on measured solubility values, and the results were discussed in more detail as compared to the automated laser-based system. Within the framework of unavoidable uncertainties of solubility testing, it is a possibility to combine minimal experimental testing that is preferably automated with mathematical modeling. That is a practical suggestion to support future pharmaceutical development in a more efficient way. © 2023, The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.
Schlagwörter
Automated setup, Data fluctuation, Robotic testing
Fachgebiet (DDC)
600 - Technik, Medizin, angewandte Wissenschaften
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
1530-9932
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Closed
Lizenz
Zitation
RAHIMPOUR, Elaheh, Milad MORADI, Atefeh SHEIKHI-SOVARI, Homa REZAEI, Hadis REZAEI, Vahid JOUYBAN-GHARAMALEKI, Martin KUENTZ und Abolghasem JOUYBAN, 2023. Comparative drug solubility studies using shake-flask versus a laser-based robotic method. AAPS PharmSciTech. 2023. Bd. 24, Nr. 7. DOI 10.1208/s12249-023-02667-9. Verfügbar unter: https://irf.fhnw.ch/handle/11654/44028