Effect of a chronic Intake of the natural sweeteners Xylitol and Erythritol on glucose absorption in humans with obesity
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Authors
Bordier, Valentine
Teysseire, Fabienne
Beglinger, Christoph
Meyer-Gerspach, Anne-Christin
Wölnerhanssen, Bettina
Senner, Frank
Author (Corporation)
Publication date
05.11.2021
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Type
01A - Journal article
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Parent work
Nutrients
Special issue
DOI of the original publication
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Series
Series number
Volume
13
Issue / Number
Pages / Duration
1-10
Patent number
Publisher / Publishing institution
MDPI
Place of publication / Event location
Basel
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Abstract
In patients with obesity, accelerated nutrients absorption is observed. Xylitol and erythritol
are of interest as alternative sweeteners, and it has been shown in rodent models that their acute in-
gestion reduces intestinal glucose absorption. This study aims to investigate whether a chronic intake
of xylitol and erythritol impacts glucose absorption in humans with obesity. Forty-six participants
were randomized to take either 8 g of xylitol or 12 g of erythritol three times a day for five to seven
weeks, or to be part of the control group (no substance). Before and after the intervention, intestinal
glucose absorption was assessed during an oral glucose tolerance test with 3-Ortho-methyl-glucose
(3-OMG). The effect of xylitol or erythritol intake on the area under the curve for 3-OMG concentra-
tion was not significant. Neither the time (pre or post intervention), nor the group (control, xylitol,
or erythritol), nor the time-by-group interaction effects were significant (p = 0.829, p = 0.821, and
p = 0.572, respectively). Therefore, our results show that a chronic intake of the natural sweeteners
xylitol and erythritol does not affect intestinal glucose absorption in humans with obesity
Keywords
3-OMG, Erythritol, Xylitol, Natural sweeteners, Glucose absorption, Obesity
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ISBN
ISSN
2072-6643
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Gold
License
Citation
Bordier, V., Teysseire, F., Schlotterbeck, G., Beglinger, C., Meyer-Gerspach, A.-C., Wölnerhanssen, B., & Senner, F. (2021). Effect of a chronic Intake of the natural sweeteners Xylitol and Erythritol on glucose absorption in humans with obesity. Nutrients, 13, 1–10. https://doi.org/10.3390/nu13113950