An origami like 3D patterned cellulose-based scaffold for bioengineering cardiovascular applications
Author (Corporation)
Publication date
2023
Typ of student thesis
Course of study
Collections
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Cellulose
Special issue
DOI of the original publication
Link
Series
Series number
Volume
30
Issue / Number
16
Pages / Duration
10401–10412
Patent number
Publisher / Publishing institution
Springer
Place of publication / Event location
Edition
Version
Programming language
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Practice partner / Client
Abstract
In this work we describe the manufacturing of cellulosic, cell compatible scaffolds with an inherent 3D origami crease pattern for applications in cardiac tissue engineering. Different cellulosic materials were studied, among them cotton linters, fibers obtained from eucalyptus, pine, spruce and lyocell. Formed sheets made of cotton linters were chosen for further study due to the highest biocompatibility and mechanical properties best suited for cardiomyocytes in wet and dry conditions: E - modulus of 0.8 GPa, tensile strength of 4.7 MPa and tensile strength in wet environment of 2.28 MPa. Cell alignment is desired to achieve directional contraction of the cardiac tissue, and several options were investigated to achieve fiber alignment, e.g. a dynamic sheet former and Rapid Köthen sheet former. Although the orientation was minimal, cells cultured on the cellulose fibers grew and aligned along the fibers. Origami inspired crease patterns were applied to the cellulose scaffolds in order to introduce directional flexibility beneficial for cardiac contraction. The transfer of a Miura-ori crease pattern was successfully applied in two ways: folding of the dried sheet between PET foils pre-formed in a 3D printed mold, and in situ wet fiber molding on a 3D-patterned mesh mounted in the sheet former’s sieve section. The latter approach enables upscaling for potential mass production.
Keywords
Subject (DDC)
600 - Technik, Medizin, angewandte Wissenschaften
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ISBN
ISSN
0969-0239
1572-882X
1572-882X
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Hybrid
License
Citation
RODRIGUEZ, Gabriela Melo, Donata TRUEB, Joachim KÖSER, Joachim SCHOELKOPF und Maurizio GULLO, 2023. An origami like 3D patterned cellulose-based scaffold for bioengineering cardiovascular applications. Cellulose. 2023. Bd. 30, Nr. 16, S. 10401–10412. DOI 10.1007/s10570-023-05492-2. Verfügbar unter: https://doi.org/10.26041/fhnw-7906