Analysis of the physical characteristics of an anhydrous vehicle for compounded pediatric oral liquids

Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Pharmaceutics
Special issue
DOI of the original publication
Link
Series
Series number
Volume
15
Issue / Number
11
Pages / Duration
Patent number
Publisher / Publishing institution
MDPI
Place of publication / Event location
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Abstract
The paucity of suitable drug formulations for pediatric patients generates a need for customized, compounded medications. This research study was set out to comprehensively analyze the physical properties of the new, proprietary anhydrous oral vehicle SuspendIt® Anhydrous, which was designed for compounding pediatric oral liquids. A wide range of tests was used, including sedimentation volume, viscosity, droplet size after dispersion in simulated gastric fluid, microscopic examination and content uniformity measurements to evaluate the properties of the anhydrous vehicle. The results showed that the vehicle exhibited consistent physical properties under varying conditions and maintained stability over time. This can be attributed to the unique blend of excipients in its formulation, which not only maintain its viscosity but also confer thixotropic behavior. The unique combination of viscous, thixotropic and self-emulsifying properties allows for rapid redispersibility, sedimentation stability, accurate dosing, potential drug solubility, dispersion and promotion of enhanced gastrointestinal distribution and absorption. Furthermore, the vehicle demonstrated long-term sedimentation stability and content uniformity for a list of 13 anhydrous suspensions. These results suggest that the anhydrous oral vehicle could serve as a versatile base for pediatric formulation, potentially filling an important gap in pediatric drug delivery. Future studies can further investigate its compatibility, stability and performance with other drugs and in different clinical scenarios.
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ISBN
ISSN
1999-4923
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Gold
License
'https://creativecommons.org/licenses/by/4.0/'
Citation
Banov, D., Liu, Y., Ip, K., Shan, A., Vu, C., Zdoryk, O., Bassani, A. S., & Carvalho, M. (2023). Analysis of the physical characteristics of an anhydrous vehicle for compounded pediatric oral liquids. Pharmaceutics, 15(11). https://doi.org/10.3390/pharmaceutics15112642