Bone regeneration by the osteoconductivity of porous titanium implants manufactured by selective laser melting: A histological and µCT study in the rabbit
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Authors
Kyrill, Maier
Thoma, Daniel
Bredell, Marius
Kruse, Astrid
Grätz, Klaus
Weber, Franz
Author (Corporation)
Publication date
2013
Typ of student thesis
Course of study
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Tissue Engineering. Part A
Special issue
DOI of the original publication
Link
Series
Series number
Volume
19
Issue / Number
23-24
Pages / Duration
2645-54
Patent number
Publisher / Publishing institution
Mary Ann Liebert
Place of publication / Event location
Edition
Version
Programming language
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Practice partner / Client
Abstract
The treatment of large bone defects still poses a major challenge in orthopaedic and cranio-maxillofacial surgery. One possible solution could be the development of personalized porous titanium-based implants that are designed to meet all mechanical needs with a minimum amount of titanium and maximum osteopromotive properties so that it could be combined with growth factor-loaded hydrogels or cell constructs to realize advanced bone tissue engineering strategies. Such implants could prove useful for mandibular reconstruction, spinal fusion, the treatment of extended long bone defects, or to fill in gaps created on autograft harvesting. The aim of this study was to determine the mechanical properties and potential of bone formation of light weight implants generated by selective laser melting (SLM). We mainly focused on osteoconduction, as this is a key feature in bone healing and could serve as a back-up for osteoinduction and cell transplantation strategies. To that end, defined implants were produced by SLM, and their surfaces were left untreated, sandblasted, or sandblasted/acid etched. In vivo bone formation with the different implants was tested throughout calvarial defects in rabbits and compared with untreated defects. Analysis by micro computed tomography (µCT) and histomorphometry revealed that all generatively produced porous Ti structures were well osseointegrated into the surrounding bone. The histomorphometric analysis revealed that bone formation was significantly increased in all implant-treated groups compared with untreated defects and significantly increased in sand blasted
implants compared with untreated ones. Bone bridging was significantly increased in sand blasted acid-etched scaffolds. Therefore, scaffolds manufactured by SLM should be surface treated. Bone augmentation beyond the original bone margins was only seen in implant-treated defects, indicating an osteoconductive potential of the implants that could be utilized clinically for bone augmentation purposes. Therefore, designed porous, lightweight structures have potential for bone regeneration and augmentation purposes, especially when complex and patient-specific geometries are essential.
Keywords
slm, bone ingrowth, Osteoconductivity
Subject (DDC)
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ISBN
ISSN
1937-335X
1937-3341
1937-3341
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
License
Citation
de Wild, M., Schumacher, R., Kyrill, M., Schkommodau, E., Thoma, D., Bredell, M., Kruse, A., Grätz, K., & Weber, F. (2013). Bone regeneration by the osteoconductivity of porous titanium implants manufactured by selective laser melting: A histological and µCT study in the rabbit. Tissue Engineering. Part A, 19(23-24), 2645–2654. https://doi.org/10.1089/ten.TEA.2012.0753