Rational selection of bio-enabling oral drug formulations. A PEARRL commentary

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Authors
Holm, Rene
Saal, Christoph
Griffin, Brendan
Author (Corporation)
Publication date
05/2021
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Type
01A - Journal article
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Parent work
Journal of Pharmaceutical Sciences
Special issue
DOI of the original publication
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Series
Series number
Volume
110
Issue / Number
5
Pages / Duration
1921-1930
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Publisher / Publishing institution
Elsevier
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Abstract
New drug candidates often require bio-enabling formation technologies such as lipid-based formulations, solid dispersions, or nanosized drug formulations. Development of such more sophisticated delivery systems generally requires higher resource investment compared to a conventional oral dosage form, which might slow down clinical development. To achieve the biopharmaceutical objectives while enabling rapid cost effective development, it is imperative to identify a suitable formulation technique for a given drug candidate as early as possible. Hence many companies have developed internal decision trees based mostly on prior organizational experience, though they also contain some arbitrary elements. As part of the EU funded PEARRL project, a number of new decision trees are here proposed that reflect both the current scientific state of the art and a consensus among the industrial project partners. This commentary presents and discusses these, while also going beyond this classical expert approach with a pilot study using emerging machine learning, where the computer suggests formulation strategy based on the physicochemical and biopharmaceutical properties of a molecule. Current limitations are discussed and an outlook is provided for likely future developments in this emerging field of pharmaceutics.
Keywords
Bioavailability, Dissolution, Formulation, In silico modeling, Lipid-based formulation, Physicochemical properties, Solid dosage forms
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ISSN
0022-3549
1520-6017
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
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Peer review of the complete publication
Open access category
Closed
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Citation
KUENTZ, Martin, Christian KRONSEDER, Rene HOLM, Christoph SAAL und Brendan GRIFFIN, 2021. Rational selection of bio-enabling oral drug formulations. A PEARRL commentary. Journal of Pharmaceutical Sciences. Mai 2021. Bd. 110, Nr. 5, S. 1921–1930. DOI 10.1016/j.xphs.2021.02.004. Verfügbar unter: https://irf.fhnw.ch/handle/11654/33335