Design of miniaturized electro spray instrument for gene and drug therapeutic treatment of IPF

dc.contributor.authorFiave, Prosper Agbesi
dc.contributor.authorBoehringer, Stephan
dc.contributor.authorGazdhar, Amiq
dc.contributor.authorGeiser, Thomas
dc.contributor.authorHradetzky, David
dc.date.accessioned2024-08-13T08:27:26Z
dc.date.available2024-08-13T08:27:26Z
dc.date.issued2013
dc.description.abstractElectric field accelerated plasmid droplets to permeate tissues has been demonstrated on cell culture and ex-vivo lung tissue of rats using enhanced green fluorescence protein reporter gene for transfection. This opens a window of opportunity to design an electrospray instrument usable within the working channel of bronchoscope to noninvasively treat idiopathic pulmonary fibrosis (IPF). We elaborate a concept and realized a device usable in the working channel of a flexible bronchoscope taking into account restrictions within typical bronchoscopy procedure.
dc.identifier.doi10.1515/bmt-2013-4041
dc.identifier.issn1862-278X
dc.identifier.issn0013-5585
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/46695
dc.issue1
dc.language.isoen
dc.publisherDe Gruyter
dc.relation.ispartofBiomedical Engineering / Biomedizinische Technik
dc.subjectGene delivery method
dc.subjectIdiopathic pulmonary fibriosis
dc.subjectBronchoscopy
dc.subject.ddc600 - Technik, Medizin, angewandte Wissenschaften
dc.titleDesign of miniaturized electro spray instrument for gene and drug therapeutic treatment of IPF
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dc.volume85
dspace.entity.typePublication
fhnw.InventedHereYes
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.affiliation.hochschuleHochschule für Life Sciences FHNWde_CH
fhnw.affiliation.institutInstitut für Medizintechnik und Medizininformatikde_CH
fhnw.openAccessCategoryClosed
fhnw.publicationStatePublished
relation.isAuthorOfPublicationc9dfc5bf-b9cd-4a1b-b606-eee6c639fd56
relation.isAuthorOfPublication.latestForDiscoveryc9dfc5bf-b9cd-4a1b-b606-eee6c639fd56
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