Multifractal Characterization of Pharmaceutical Hot-Melt Extrudates

dc.accessRightsAnonymous
dc.audienceScience
dc.contributor.authorAdler, Camille
dc.contributor.authorKuentz, Martin
dc.contributor.authorTeleki, Alexandra
dc.date.accessioned2016-12-16T11:01:27Z
dc.date.available2016-12-16T11:01:27Z
dc.date.issued2016
dc.description.abstractPURPOSE: Multifractal geometry has become a powerful tool to describe complex structures in many fields. Our first aim was to combine imaging and multifractal analysis to better understand the microstructure of pharmaceutical extrudates. A second objective was to study erosion/dispersion behavior of the formulations because it would condition release of any drug. METHODS: Different formulations containing a lipid, a polymer and different silica based inorganic carriers were produced by hot-melt extrusion at various screw speeds. Multifractal analysis was based on scanning electron microscopy/energy dispersive X-Ray spectroscopy images. This microstructural analysis was complemented with dynamic optical imaging of formulation erosion/dispersion behavior. RESULTS: Multifractal analysis indicated that inorganic carrier type and concentration as well as the screw speed affected the microstructure of the extrudates. The aqueous erosion/dispersion study showed that only the type and concentration of inorganic carrier were important. CONCLUSIONS: The use of microstructural and dispersion analysis appeared to be complementary to better characterize and understand complex formulations obtained by hot-melt extrusion.
dc.description.urihttp://link.springer.com/article/10.1007%2Fs11095-016-2064-4
dc.identifier.issn0724-8741
dc.identifier.issn1573-904X
dc.identifier.urihttp://hdl.handle.net/11654/23742
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofPharmaceutical Researchen_US
dc.subjectdispersion
dc.subjecthot-melt extrusion
dc.subjectinorganic carrier
dc.subjectmultifractal
dc.subjectscanning electron microscopy
dc.titleMultifractal Characterization of Pharmaceutical Hot-Melt Extrudates
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dspace.entity.typePublication
fhnw.InventedHereYes
fhnw.IsStudentsWorkno
fhnw.PublishedSwitzerlandNo
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.affiliation.hochschuleHochschule für Life Sciencesde_CH
fhnw.affiliation.institutInstitut für Pharma Technologyde_CH
fhnw.publicationOnlineJa
fhnw.publicationStatePublished
relation.isAuthorOfPublication68819448-8611-488b-87bc-1b1cf9a6a1b4
relation.isAuthorOfPublication.latestForDiscovery68819448-8611-488b-87bc-1b1cf9a6a1b4
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