Absorption and metabolism of the natural sweeteners erythritol and xylitol in humans. A dose-ranging study
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Authors
Wölnerhanssen, Bettina K.
Meyer-Gerspach, Anne Christin
Bordier, Valentine
Teysseire, Valentine
Senner, Frank
Drewe, Jürgen
Beglinger, Christoph
Author (Corporation)
Publication date
30.08.2022
Typ of student thesis
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Type
01A - Journal article
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Parent work
International Journal of Molecular Sciences
Special issue
DOI of the original publication
Link
Series
Series number
Volume
23
Issue / Number
17
Pages / Duration
1-13
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Publisher / Publishing institution
MDPI
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Abstract
The natural sweeteners erythritol and xylitol might be helpful to reduce sugar consumption and therefore prevent obesity and diabetes. The aim of the present study was to determine the absorption and metabolization into erythronate of different concentrations of erythritol and xylitol. Seventeen healthy lean participants received intragastric solutions of 10, 25, or 50 g erythritol or 7, 17, or 35 g xylitol on three study days in a randomized order. The study was double blinded with respect to the doses administered. We assessed plasma concentrations of erythritol, xylitol, and erythronate at fixed time intervals after administration with gas chromatography-mass spectrometry. We found: (i) a dose-dependent and saturable absorption of erythritol, (ii) a very low absorption of xylitol, (iii) a dose-dependent metabolization of erythritol into erythronate, and (iv) no metabolization of xylitol into erythronate. The implications of the metabolization of erythritol into erythronate for human health remain to be determined and more research in this area is needed.
Keywords
Erythritol, Xylitol, Erythronate, Natural sweeteners, Absorption, Metabolism, Obesity, Diabetes
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ISBN
ISSN
1422-0067
1661-6596
1661-6596
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Gold
License
Citation
Wölnerhanssen, B. K., Meyer-Gerspach, A. C., Bordier, V., Teysseire, V., Senner, F., Schlotterbeck, G., Drewe, J., & Beglinger, C. (2022). Absorption and metabolism of the natural sweeteners erythritol and xylitol in humans. A dose-ranging study. International Journal of Molecular Sciences, 23(17), 1–13. https://doi.org/10.3390/ijms23179867