Regions of attainable particle sizes in continuous and batch crystallization processes
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Author (Corporation)
Publication date
17.03.2014
Type of student thesis
Course of study
Type
01A - Journal article
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Parent work
Chemical Engineering Science
Special issue
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Series
Series number
Volume
106
Issue / Number
Pages / Duration
167-180
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Publisher / Publishing institution
Elsevier
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Abstract
Process alternatives for continuous crystallization, i.e., cascades of mixed suspension, mixed product removal crystallizers (MSMPRCs) and plug flow crystallizers (PFCs), as well as batch crystallizers are discussed and modeled using population balance equations. The attainable region approach that has previously been used in the design of chemical reactor networks and separation systems is applied to the above-mentioned alternatives for crystallization processes in order to identify attainable regions in a diagram of mean product particle size vs. total process residence time. It is demonstrated that the boundaries of these attainable regions can be found numerically by solving appropriate optimization problems and that the region enclosed by these boundaries is fully accessible. Knowing the attainable region of particle sizes, it is possible to generate feasible process alternatives that allow specific particle sizes to be obtained in a given process configuration. The attainable regions presented in this paper are useful to determine whether a desired mean particle size can be achieved in a specific crystallizer type. The concept of the attainable region is illustrated on three case studies: the cooling crystallization of paracetamol grown from ethanol, the anti-solvent crystallization of L -asparagine monohydrate from water using isopropanol as the anti-solvent and the combined cooling/anti-solvent crystallization of aspirin from ethanol using water as the anti-solvent.
Keywords
Attainable region, Process design, Particle size distribution, Continuous crystallization, Batch crystallization
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ISBN
ISSN
0009-2509
Language
English
Created during FHNW affiliation
No
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Green
License
Citation
Vetter, T., Burcham, C. L., & Doherty, M. F. (2014). Regions of attainable particle sizes in continuous and batch crystallization processes. Chemical Engineering Science, 106, 167–180. https://doi.org/10.1016/j.ces.2013.11.008