Precision and uncertainties for moving targets
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Authors
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Publication date
2025
Typ of student thesis
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Type
04A - Book part
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Parent work
Proton therapy physics
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DOI of the original publication
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Series
Series in medical physics and biomedical engineering
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Volume
Issue / Number
Pages / Duration
496-521
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Publisher / Publishing institution
CRC Press
Place of publication / Event location
Boca Raton
Edition
3rd Edition
Version
Programming language
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Practice partner / Client
Abstract
This chapter discusses time-dependent variations of the target location and the patient's density distribution and its consequences during proton therapy treatments. Variations can occur on different timescales; i.e., over the entire treatment course (weight loss/gain, treatment response of the target), between subsequent treatment fractions (interfractional motion like setup variations or changes in cavity fillings), and within a treatment fraction (intrafractional motion due to heartbeat, breathing, or relaxation). This chapter mainly focuses on intrafractional motion. At the moment, motion in proton radiotherapy is a problem that has not yet been completely solved. A variety of strategies have been discussed to mitigate the effects of motion in proton radiotherapy. The best approach to deal with motion will depend on the tumor sites and the configuration of a specific proton treatment facility, and is likely a combination of strategies discussed in this chapter. First clinical experience indicates that previous in silico studies might have overestimated the dosimetric impact of motion by investigating its effects individually instead of embedded in realistic treatment scenarios. This chapter reviews the research and summarizes the current clinical practice related to the treatment of moving targets with proton therapy.
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ISBN
978-1-0326-1685-8
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Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
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Peer review of the complete publication
Open access category
Closed
License
Citation
Knopf, A., & Meijers, A. (2025). Precision and uncertainties for moving targets. In H. Paganetti (Ed.), Proton therapy physics (3rd Edition, pp. 496–521). CRC Press. https://doi.org/10.1201/9781032616858-27