Assessment of the bony resection margin distance in bone-invasive oral cancer using laser-induced breakdown spectroscopy

dc.contributor.authorWinnand, Philipp
dc.contributor.authorOoms, Mark
dc.contributor.authorHeitzer, Marius
dc.contributor.authorVohl, Nils
dc.contributor.authorLammert, Matthias
dc.contributor.authorHölzle, Frank
dc.contributor.authorBörnsen, Klaus Olaf
dc.contributor.authorModabber, Ali
dc.date.accessioned2025-03-10T14:36:20Z
dc.date.issued2024-08-08
dc.description.abstractObjectives Inadequate resection margins of less than 5 mm impair local tumor control. This weak point in oncological safety is exacerbated in bone-infiltrating tumors because rapid bone analysis procedures do not exist. This study aims to assess the bony resection margin status of bone-invasive oral cancer using laser-induced breakdown spectroscopy (LIBS). Materials and methods LIBS experiments were performed on natively lasered, tumor-infiltrated mandibular cross-sections from 10 patients. In total, 5,336 spectra were recorded at defined distances from the tumor border. Resection margins < 1 mm were defined as very close, from 1–5 mm as close, and > 5 mm as clear. The spectra were histologically validated. Based on the LIBS spectra, the discriminatory power of potassium (K) and soluble calcium (Ca) between bone-infiltrating tumor tissue and very close, close, and clear resection margins was determined. Results LIBS-derived electrolyte emission values of K and soluble Ca as well as histological parameters for bone neogenesis/fibrosis and lymphocyte/macrophage infiltrates differ significantly between bone-infiltrating tumor tissue spectra and healthy bone spectra from very close, close, and clear resection margins (p < 0.0001). Using LIBS, the transition from very close resection margins to bone-infiltrating tumor tissue can be determined with a sensitivity of 95.0%, and the transition from clear to close resection margins can be determined with a sensitivity of 85.3%. Conclusions LIBS can reliably determine the boundary of bone-infiltrating tumors and might provide an orientation for determining a clear resection margin. Clinical relevance LIBS could facilitate intraoperative decision-making and avoid inadequate resection margins in bone-invasive oral cancer.
dc.identifier.doi10.1007/s00784-024-05862-5
dc.identifier.issn1436-3771
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/50042
dc.identifier.urihttps://doi.org/10.26041/fhnw-11886
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofClinical Oral Investigations
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleAssessment of the bony resection margin distance in bone-invasive oral cancer using laser-induced breakdown spectroscopy
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift
dc.volume28
dspace.entity.typePublication
fhnw.InventedHereYes
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.affiliation.hochschuleHochschule für Life Sciences FHNWde_CH
fhnw.affiliation.institutInstitut für Chemie und Bioanalytikde_CH
fhnw.openAccessCategoryHybrid
fhnw.publicationStatePublished
relation.isAuthorOfPublicationb18cce70-2e3d-49f8-9077-b63baee620f2
relation.isAuthorOfPublication.latestForDiscoveryb18cce70-2e3d-49f8-9077-b63baee620f2
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