Measuring multidimensional particle size distributions during crystallization
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Autor:innen
Autor:in (Körperschaft)
Publikationsdatum
30.07.2012
Typ der Arbeit
Studiengang
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Chemical Engineering Science
Themenheft
DOI der Originalpublikation
Link
Zugehörige Forschungsdaten
Reihe / Serie
Reihennummer
Jahrgang / Band
77
Ausgabe / Nummer
Seiten / Dauer
130-142
Patentnummer
Verlag / Herausgebende Institution
Elsevier
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
A protocol for measuring multidimensional particle size distributions during crystallization is presented. The instrument consists of a flow through cell where it is possible to take images of particles in suspension from two perpendicular directions. The flow through cell is connected to a batch crystallizer through a sampling loop and a dilution system that allow tuning the suspension density in the cell for the sake of image quality. The images thus obtained are analyzed with a fast image analysis algorithm and characteristic lengths of particles are calculated. Generic geometric shapes representing different types of crystals are defined as particle classes. We present a method to classify particles into these classes, which enables for instance to differentiate between different polymorphs of a substance when their shape is different. The capabilities of the measurement device and of the algorithm are illustrated by comparing their performance to standard measurement tools like a Coulter Multisizer. The comparison shows that the two instruments give the same result. The effectiveness and accuracy of the protocol proposed is assessed by monitoring size and shape of crystals of acetylsalicylic acid and of paracetamol during seeded cooling crystallization.
Schlagwörter
Fachgebiet (DDC)
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
0009-2509
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Nein
Zukunftsfelder FHNW
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Closed
Lizenz
Zitation
Schorsch, S., Vetter, T., & Mazzotti, M. (2012). Measuring multidimensional particle size distributions during crystallization. Chemical Engineering Science, 77, 130–142. https://doi.org/10.1016/j.ces.2011.11.029