New scale-up technologies for hydrogenation reactions in multipurpose pharmaceutical production plants
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Authors
Author (Corporation)
Publication date
2021
Typ of student thesis
Course of study
Collections
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Chimia
Special issue
DOI of the original publication
Link
Series
Series number
Volume
75
Issue / Number
11
Pages / Duration
948-956
Patent number
Publisher / Publishing institution
Schweizerische Chemische Gesellschaft
Place of publication / Event location
Bern
Edition
Version
Programming language
Assignee
Practice partner / Client
Abstract
The classical scale-up approach for hydrogenation reaction processes usually includes numerous laboratory- and pilot-scale experiments. With a novel scale-up strategy, a significant number of these experiments may be replaced by modern computational simulations in combination with scale-down experiments. With only a few laboratory-scale experiments and information about the production-scale reactor, a chemical process model is developed. This computational model can be used to simulate the production-scale process with a range of different process parameters. Those simulations are then validated by only a few experiments in an advanced scale-down reactor. The scale-down reactor has to be geometrically identical to the corresponding production-scale reactor and should show a similar mass transfer behaviour. Closest similarity in terms of heat transfer behaviour is ensured by a sophisticated 3D-printed heating/cooling finger, offering the same heat exchange area per volume and overall heat-transfer coefficient as in production-scale. The proposed scale-up strategy and the custom-designed scale-down reactor will be tested by proof of concept with model reactions. Those results will be described in a future publication. This project is an excellent example of a collaboration between academia and industry, which was funded by the Aargau Research Fund. The interest of academia is to study and understand all physical and chemical processes involved, whereas industry is interested in generating a robust and simple to use tool to improve scale-up and make reliable predictions.
Keywords
Agitated Vessel, Hydrogenation, Process Modelling, Quality By Design (QBD), Scale-Up / Scale-Down
Subject (DDC)
Event
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ISBN
ISSN
2673-2424
0009-4293
0009-4293
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Diamond
License
Citation
Furrer, T., Müller, B., Hasler, C., Berger, B., Levis, M. K., & Zogg, A. (2021). New scale-up technologies for hydrogenation reactions in multipurpose pharmaceutical production plants. Chimia, 75(11), 948–956. https://doi.org/10.2533/chimia.2021.948