New scale-up technologies for hydrogenation reactions in multipurpose pharmaceutical production plants
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Autor:innen
Autor:in (Körperschaft)
Publikationsdatum
2021
Typ der Arbeit
Studiengang
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Chimia
Themenheft
DOI der Originalpublikation
Link
Reihe / Serie
Reihennummer
Jahrgang / Band
75
Ausgabe / Nummer
11
Seiten / Dauer
948-956
Patentnummer
Verlag / Herausgebende Institution
Schweizerische Chemische Gesellschaft
Verlagsort / Veranstaltungsort
Bern
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
The classical scale-up approach for hydrogenation reaction processes usually includes numerous laboratory- and pilot-scale experiments. With a novel scale-up strategy, a significant number of these experiments may be replaced by modern computational simulations in combination with scale-down experiments. With only a few laboratory-scale experiments and information about the production-scale reactor, a chemical process model is developed. This computational model can be used to simulate the production-scale process with a range of different process parameters. Those simulations are then validated by only a few experiments in an advanced scale-down reactor. The scale-down reactor has to be geometrically identical to the corresponding production-scale reactor and should show a similar mass transfer behaviour. Closest similarity in terms of heat transfer behaviour is ensured by a sophisticated 3D-printed heating/cooling finger, offering the same heat exchange area per volume and overall heat-transfer coefficient as in production-scale. The proposed scale-up strategy and the custom-designed scale-down reactor will be tested by proof of concept with model reactions. Those results will be described in a future publication. This project is an excellent example of a collaboration between academia and industry, which was funded by the Aargau Research Fund. The interest of academia is to study and understand all physical and chemical processes involved, whereas industry is interested in generating a robust and simple to use tool to improve scale-up and make reliable predictions.
Schlagwörter
Agitated Vessel, Hydrogenation, Process Modelling, Quality By Design (QBD), Scale-Up / Scale-Down
Fachgebiet (DDC)
540 - Chemie
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
2673-2424
0009-4293
0009-4293
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Diamond
Lizenz
Zitation
FURRER, Thierry, Benedikt MÜLLER, Christoph HASLER, Bernhard BERGER, Michael Karl LEVIS und Andreas ZOGG, 2021. New scale-up technologies for hydrogenation reactions in multipurpose pharmaceutical production plants. Chimia. 2021. Bd. 75, Nr. 11, S. 948–956. DOI 10.2533/chimia.2021.948. Verfügbar unter: https://doi.org/10.26041/fhnw-3938