Benefits of Fractal Approaches in Solid Dosage Form Development
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Authors
Abreu-Villela, Renata
Author (Corporation)
Publication date
06.09.2019
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Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Pharmaceutical Research
Special issue
DOI of the original publication
Series
Series number
Volume
36
Issue / Number
11
Pages / Duration
156
Patent number
Publisher / Publishing institution
Springer
Place of publication / Event location
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Abstract
Pharmaceutical formulations are complex systems consisting of active pharmaceutical ingredient(s) and a number of excipients selected to provide the intended performance of the product. The understanding of materials' properties and technological processes is a requirement for building quality into pharmaceutical products. Such understanding is gained mostly from empirical correlations of material and process factors with quality attributes of the final product. However, it seems also important to gain knowledge based on mechanistic considerations. Promising is here to study morphological and/or topological characteristics of particles and their aggregates. These geometric aspects must be taken into account to better understand how product attributes emerge from raw materials, which includes, for example, mechanical tablet properties, disintegration or dissolution behavior. Regulatory agencies worldwide are promoting the use of physical models in pharmaceutics to design quality into a final product. This review deals with pharmaceutical applications of theoretical models, focusing on percolation theory, fractal, and multifractal geometry. The use of these so-called fractal approaches improves the understanding of different aspects in the development of solid dosage forms, for example by identifying critical drug and excipient concentrations, as well as to study effects of heterogeneity on dosage form performance. The aim is to link micro- and macrostructure to the emerging quality attributes of the pharmaceutical solid dosage forms as a strategy to enhance mechanistic understanding and to advance pharmaceutical development and manufacturing processes.
Keywords
fractal geometry, fractal-like kinetics, geometric distribution, percolation theory, solid dosage forms
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ISBN
ISSN
0724-8741
1573-904X
1573-904X
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
License
Citation
Abreu-Villela, R., & Kuentz, M. (2019). Benefits of Fractal Approaches in Solid Dosage Form Development. Pharmaceutical Research, 36(11), 156. https://doi.org/10.1007/s11095-019-2685-5