Design and performance assessment of continuous crystallization processes resolving racemic conglomerates
Loading...
Authors
Author (Corporation)
Publication date
12.02.2018
Type of student thesis
Course of study
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Crystal Growth & Design
Special issue
DOI of the original publication
Link
Related research data
Series
Series number
Volume
18
Issue / Number
3
Pages / Duration
Patent number
Publisher / Publishing institution
American Chemical Society
Place of publication / Event location
Edition
Version
Programming language
Assignee
Practice partner / Client
Abstract
Continuous crystallization processes achieving the complete resolution of racemic feed mixtures of conglomerate forming substances are presented. The processes considered rely on the principles of preferential crystallization or attrition-enhanced deracemization (Viedma ripening). A single mechanistic population balance model is shown to describe both operating modes. For the case of isothermal Viedma ripening, a shortcut method is introduced that allows the rapid and computationally efficient design of processes using a single or multiple ripening stages. The achievable productivity and enantiomeric purity are determined for all process variants in a wide range of operating conditions, and Pareto optimal operating points are identified. Since our results are obtained with a consistent set of kinetics for all operating modes, an unbiased comparison is enabled. It is shown that the productivity of the ripening process can be improved by using cascades of multiple crystallizers, but that the preferential crystallization process still achieves higher productivity at full enantiomeric purity.
Keywords
Crystallization, Molecular structure, Ripening, Separation science, Suspensions
Subject (DDC)
Event
Exhibition start date
Exhibition end date
Conference start date
Conference end date
Date of the last check
ISBN
ISSN
1528-7483
1528-7505
1528-7505
Language
English
Created during FHNW affiliation
No
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Closed
License
Citation
Köllges, T., & Vetter, T. (2018). Design and performance assessment of continuous crystallization processes resolving racemic conglomerates. Crystal Growth & Design, 18(3). https://doi.org/10.1021/acs.cgd.7b01618