Bioinformatic and statistical analysis of adaptive immune repertoires

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Publication date
10/2015
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01A - Journal article
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Trends in Immunology
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Volume
36
Issue / Number
11
Pages / Duration
738-749
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Cell Press
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Abstract
High-throughput sequencing (HTS) of immune repertoires has enabled the quantitative analysis of adaptive immune responses and offers the potential to revolutionize research in lymphocyte biology, vaccine profiling, and mono clonal antibody engineering. Advances in sequencing technology coupled to an exponential decline in sequencing costs have fueled the recent over whelming interest in immune repertoire sequencing. This, in turn, has sparked the development of numerous methods for bioinformatic and statistics-driven interpretation and visualization of immune repertoires. Here, we review the current literature on bioinformatic and statistical analysis of immune reper toire HTS data and discuss underlying assumptions, applicability, and scope. We further highlight important directions for future research, which could propel immune repertoire HTS to becoming a standard method for measuring adaptive immune responses.
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1471-4906
1471-4981
Language
English
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Yes
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Published
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Closed
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Citation
Greiff, V., Miho, E., Menzel, U., & Reddy, S. T. (2015). Bioinformatic and statistical analysis of adaptive immune repertoires. Trends in Immunology, 36(11), 738–749. https://doi.org/10.1016/j.it.2015.09.006