Modified oligonucleotides
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08.01.1998
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12 - Patent
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WO9800434
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World Intellectual Property Organization
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Novartis AG
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Abstract
It is one object of the present invention to provide an oligonucleotide of formula (1): 5'-(U)n-3' in which U is an identical or different radical of a natural or a synthetic nucleoside, wherein the oligonucleotide comprises at least one modified nucleotide dimer comprising two nucleoside analogs connected via an amide-bond that has a certain configuration; the synthesis of these compounds and their use in pharmaceutical preparations.
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Citation
De Mesmaeker, A., Wendeborn, S., & Lebreton, J. (1998). Modified oligonucleotides. World Intellectual Property Organization. https://doi.org/10.26041/fhnw-9970