Zur Kurzanzeige

dc.contributor.authorde Wild, Michael
dc.contributor.authorHoffmann, Waldemar
dc.contributor.authorFeliciano, Sandra
dc.contributor.authorMartin, Ivan
dc.contributor.authorWendt, David
dc.date.accessioned2015-10-07T08:38:58Z
dc.date.available2015-10-07T08:38:58Z
dc.date.issued2015
dc.identifier.doi10.3389/fbioe.2015.00010
dc.identifier.urihttp://hdl.handle.net/11654/10106
dc.description.abstractSecondary bone fracture healing is a physiological process that leads to functional tissue regeneration via endochondral bone formation. In vivo studies have demonstrated that early mobilization and the application of mechanical loads enhances the process of fracture healing. However, the influence of specific mechanical stimuli and particular effects during specific phases of fracture healing remain to be elucidated. In this work, we have developed and provided proof-of-concept of an in vitro human organotypic model of physiological loading of a cartilage callus, based on a novel perfused compression bioreactor (PCB) system. We then used the fracture callus model to investigate the regulatory role of dynamic mechanical loading. Our findings provide a proof-of-principle that dynamic mechanical loading applied by the PCB can enhance the maturation process of mesenchymal stromal cells toward late hypertrophic chondrocytes and the mineralization of the deposited extracellular matrix. The PCB provides a promising tool to study fracture healing and for the in vitro assessment of alternative fracture treatments based on engineered tissue grafts or pharmaceutical compounds, allowing for the reduction of animal experiments.
dc.language.isoen
dc.relation.ispartofFrontiers in Bioengineering and Biotechnology
dc.accessRightsAnonymous
dc.subjectbioreactor, in vitro model, mechanical loading, hypertrophy, fracture healing
dc.titleNovel perfused compression bioreactor system as an in vitro model to investigate fracture healing
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.volume3
dc.issue10
dc.audienceScience
fhnw.publicationStatePublished
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandNo
fhnw.pagination1-6
fhnw.IsStudentsWorkno


Dateien zu dieser Ressource

DateienGrösseFormatAnzeige

Zu diesem Eintrag gibt es keine Dateien.

Der Eintrag erscheint in:

Zur Kurzanzeige