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dc.contributor.authorde Wild, Michael
dc.contributor.authorSchumacher, Ralf
dc.contributor.authorKyrill, Maier
dc.contributor.authorSchkommodau, Erik
dc.contributor.authorThoma, Daniel
dc.contributor.authorBredell, Marius
dc.contributor.authorKruse, Astrid
dc.contributor.authorGrätz, Klaus
dc.contributor.authorWeber, Franz
dc.date.accessioned2015-10-07T09:13:21Z
dc.date.available2015-10-07T09:13:21Z
dc.date.issued2013
dc.identifier.doi10.1089/ten.TEA.2012.0753
dc.identifier.urihttp://hdl.handle.net/11654/10110
dc.description.abstractThe treatment of large bone defects still poses a major challenge in orthopaedic and cranio-maxillofacial surgery. One possible solution could be the development of personalized porous titanium-based implants that are designed to meet all mechanical needs with a minimum amount of titanium and maximum osteopromotive properties so that it could be combined with growth factor-loaded hydrogels or cell constructs to realize advanced bone tissue engineering strategies. Such implants could prove useful for mandibular reconstruction, spinal fusion, the treatment of extended long bone defects, or to fill in gaps created on autograft harvesting. The aim of this study was to determine the mechanical properties and potential of bone formation of light weight implants generated by selective laser melting (SLM). We mainly focused on osteoconduction, as this is a key feature in bone healing and could serve as a back-up for osteoinduction and cell transplantation strategies. To that end, defined implants were produced by SLM, and their surfaces were left untreated, sandblasted, or sandblasted/acid etched. In vivo bone formation with the different implants was tested throughout calvarial defects in rabbits and compared with untreated defects. Analysis by micro computed tomography (µCT) and histomorphometry revealed that all generatively produced porous Ti structures were well osseointegrated into the surrounding bone. The histomorphometric analysis revealed that bone formation was significantly increased in all implant-treated groups compared with untreated defects and significantly increased in sand blasted implants compared with untreated ones. Bone bridging was significantly increased in sand blasted acid-etched scaffolds. Therefore, scaffolds manufactured by SLM should be surface treated. Bone augmentation beyond the original bone margins was only seen in implant-treated defects, indicating an osteoconductive potential of the implants that could be utilized clinically for bone augmentation purposes. Therefore, designed porous, lightweight structures have potential for bone regeneration and augmentation purposes, especially when complex and patient-specific geometries are essential.
dc.language.isoen
dc.relation.ispartofTissue Engineering Part A
dc.accessRightsAnonymous
dc.subjectslm, bone ingrowth, Osteoconductivity,
dc.subject.ddc570 - Biowissenschaften, Biologiede
dc.titleBone regeneration by the osteoconductivity of porous titanium implants manufactured by selective laser melting: A histological and µCT study in the rabbit
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.volume19
dc.issue23-24
dc.audienceScience
fhnw.publicationStatePublished
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandNo
fhnw.pagination2645-54
fhnw.IsStudentsWorkno


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