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dc.contributor.authorIIko, D.
dc.contributor.authorPuhl, S.
dc.contributor.authorMeinel, L.
dc.contributor.authorGermershaus, Oliver
dc.contributor.authorHolzgrabe, L.
dc.date.accessioned2015-12-22T20:14:14Z
dc.date.available2015-12-22T20:14:14Z
dc.date.issued2015-02
dc.identifier.doi10.1016/j.jpba.2014
dc.identifier.urihttp://hdl.handle.net/11654/11961
dc.description.abstractCurrently, neither the European nor the United States Pharmacopoeia provide a method for the determination of polidocanol (PD) content despite the fact that PD, besides being an excipient, is also used as an active pharmaceutical ingredient. We therefore developed a method where the PD content was determined using a Kinetex C18 column operated at 40°C with water-acetonitrile (15:85, v/v) as mobile phase. A Corona(®) charged aerosol detector was employed for the detection of PD that is lacking a suitable UV chromophore. The method was fully validated. Additionally, the method was applied for the determination of PD release from a pharmaceutical polymer matrix consisting of poly-ɛ-caprolactone and poly(lactic-co-glycolic acid) and PD.
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysis
dc.accessRightsAnonymous
dc.subjectAssay; Charged aerosol detection; Dissolution; High performance liquid chromatography; Pharmaceutical analysis; Polidocanol
dc.titleSimple and rapid high performance liquid chromatography method for the determination of polidocanol as bulk product and in pharmaceutical polymer matrices using charged aerosol detection
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.volume104
dc.audienceScience
fhnw.publicationStatePublished
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandNo
fhnw.pagination17-20
fhnw.IsStudentsWorkno


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