dc.contributor.author | Adler, Camille | |
dc.contributor.author | Kuentz, Martin | |
dc.contributor.author | Teleki, Alexandra | |
dc.date.accessioned | 2016-12-16T11:01:27Z | |
dc.date.available | 2016-12-16T11:01:27Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | http://hdl.handle.net/11654/23742 | |
dc.description.abstract | PURPOSE:
Multifractal geometry has become a powerful tool to describe complex structures in many fields. Our first aim was to combine imaging and multifractal analysis to better understand the microstructure of pharmaceutical extrudates. A second objective was to study erosion/dispersion behavior of the formulations because it would condition release of any drug.
METHODS:
Different formulations containing a lipid, a polymer and different silica based inorganic carriers were produced by hot-melt extrusion at various screw speeds. Multifractal analysis was based on scanning electron microscopy/energy dispersive X-Ray spectroscopy images. This microstructural analysis was complemented with dynamic optical imaging of formulation erosion/dispersion behavior.
RESULTS:
Multifractal analysis indicated that inorganic carrier type and concentration as well as the screw speed affected the microstructure of the extrudates. The aqueous erosion/dispersion study showed that only the type and concentration of inorganic carrier were important.
CONCLUSIONS:
The use of microstructural and dispersion analysis appeared to be complementary to better characterize and understand complex formulations obtained by hot-melt extrusion. | |
dc.description.uri | http://link.springer.com/article/10.1007%2Fs11095-016-2064-4 | |
dc.language.iso | en | |
dc.relation.ispartof | Pharmaceutical Research | en_US |
dc.accessRights | Anonymous | |
dc.subject | dispersion | |
dc.subject | hot-melt extrusion | |
dc.subject | inorganic carrier | |
dc.subject | multifractal | |
dc.subject | scanning electron microscopy | |
dc.title | Multifractal Characterization of Pharmaceutical Hot-Melt Extrudates | |
dc.type | 01 - Zeitschriftenartikel, Journalartikel oder Magazin | |
dc.audience | Science | |
fhnw.publicationState | Published | |
fhnw.ReviewType | Anonymous ex ante peer review of a complete publication | |
fhnw.InventedHere | Yes | |
fhnw.PublishedSwitzerland | No | |
fhnw.IsStudentsWork | no | |
fhnw.publicationOnline | Ja | |