Zur Kurzanzeige

dc.contributor.authorNegrini, Renata
dc.contributor.authorAleandri, Simone
dc.contributor.authorKuentz, Martin
dc.date.accessioned2018-01-10T09:31:02Z
dc.date.available2018-01-10T09:31:02Z
dc.date.issued2017
dc.identifier.doi10.1016/j.xphs.2017.07.006
dc.identifier.urihttp://hdl.handle.net/11654/25796
dc.description.abstractNanosuspensions provide a drug delivery approach to cope with erratic absorption of poorly water-soluble compounds. Despite extensive research over the last years, there are still open pharmaceutical challenges so it is often unclear how quality attributes such as viscosity and physical stability are generated, which requires a more thorough study of the colloidal structures and interactions in nanosuspensions. In this study, diffusing wave spectroscopy and microfluidics-based rheology were used for the first time to assess pharmaceutical nanosuspensions that were obtained by wet milling. Further sample characterization following centrifugation was based on optical rotatory dispersion and conductivity experiments. Ketoconazole was selected as model drug in the presence of sodium dodecyl sulfate and hydroxypropyl cellulose as anionic and steric stabilizer, respectively. The results unexpectedly showed that the investigated nanosuspensions did not behave as Einstein-like suspensions because a viscosity decrease was evidenced for increased drug load. This effect was attributed to the polymer that formed a dominating network in the bulk solution from where adsorption occurred onto particle surfaces. This depletion of bulk polymer caused the observed rheological finding. Further colloidal research should be invested into different pharmaceutical nanosuspensions to gain a more complete structural understanding and to harness their full technological potential.
dc.language.isoen_US
dc.relation.ispartofJournal of Pharmaceutical Sciences
dc.accessRightsAnonymous
dc.subjectpoorly soluble drugs
dc.subjectrheology
dc.subjectnanoparticles
dc.subjectnanomilling
dc.subjectviscosity
dc.subjectlight scattering
dc.titleStudy of rheology and polymer adsorption onto drug nanoparticles in pharmaceutical suspensions produced by nano milling
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.volume106
dc.issue11
dc.audienceScience
fhnw.publicationStatePublished
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandYes
fhnw.pagination3395–3401
fhnw.IsStudentsWorkno
fhnw.publicationOnlineJa


Dateien zu dieser Ressource

DateienGrösseFormatAnzeige

Zu diesem Eintrag gibt es keine Dateien.

Der Eintrag erscheint in:

Zur Kurzanzeige