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dc.contributor.authorCorrero, Maria Rita
dc.contributor.authorSykora, Sabine
dc.contributor.authorCorvini, Philippe
dc.contributor.authorShahgaldian, Patrick
dc.date.accessioned2018-01-23T08:50:20Z
dc.date.available2018-01-23T08:50:20Z
dc.date.issued2017-02
dc.identifier.doi10.1016/bs.mie.2016.12.006
dc.identifier.urihttp://hdl.handle.net/11654/25904
dc.description.abstractThe availability of highly stable and reusable enzymes is one of the main challenges in bio-based industrial processes. Enzyme immobilization and encapsulation represent promising strategies to reach this goal. In this chapter, the synthetic strategy to produce hybrid organic/inorganic nanobiocatalysts (NBC) is reported. This strategy is based on the sequential immobilization of an enzyme on the surface of silica nanoparticles followed by the growth, at the surface of the nanoparticles, of a shielding layer which serves as an armor to protect the enzyme against denaturation/degradation. This armor is produced through a thickness-controlled organosilane poly-condensation onto the nanoparticle surface around the enzyme to form a protective organosilica layer. The armored nanobiocatalysts present enhanced catalytic activity and improved stability against heat, pH, chaotropic agents, proteases, and ultrasound. The method is versatile in that it can be successfully adapted to a number of different enzymes.
dc.description.urihttps://www.ncbi.nlm.nih.gov/pubmed/28411651
dc.language.isoen_US
dc.relation.ispartofMethods in Enzymology
dc.accessRightsAnonymous
dc.subjectEnzyme catalysis
dc.subjectNanobiocatalysts
dc.subjectNanoparticles
dc.subjectOrganosilica
dc.subjectSelf-assembly
dc.titleEnzyme Armoring by an Organosilica Layer: Synthesis and Characterization of Hybrid Organic/Inorganic Nanobiocatalysts.
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.volume590
dc.audienceScience
fhnw.publicationStatePublished
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandNo
fhnw.pagination77-91
fhnw.IsStudentsWorkno
fhnw.publicationOnlineJa


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