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dc.contributor.authorAleandri, Simone
dc.contributor.authorSchönenberger, Monica
dc.contributor.authorNiederquell, Andreas
dc.contributor.authorKuentz, Martin
dc.date.accessioned2018-12-13T09:56:23Z
dc.date.available2018-12-13T09:56:23Z
dc.date.issued2018-02
dc.identifier.doi10.1007/s11095-017-2300-6.
dc.identifier.urihttp://hdl.handle.net/11654/26968
dc.description.abstractPurpose The trial-and-error approach is still predominantly used in pharmaceutical development of nanosuspensions. Physicochemical dispersion stability is a primary focus and therefore, various analytical bulk methods are commonly employed. Clearly less attention is directed to surface changes of nanoparticles even though such interface effects can be of pharmaceutical relevance. Such potential effects in drug nanosuspensions were to be studied for temperatures of 25 and 37°C by using complementary surface analytical methods. Methods Atomic force microscopy, inverse gas chromatography and UV surface dissolution imaging were used together for the first time to assess pharmaceutical nanosuspensions that were obtained by wet milling. Fenofibrate and bezafibrate were selected as model drugs in presence of sodium dodecyl sulfate and hydroxypropyl cellulose as anionic and steric stabilizer, respectively. Results It was demonstrated that in case of bezafibrate nanosuspension, a surface modification occurred at 37°C compared to 25°C, which notably affected dissolution rate. By contrast, no similar effect was observed in case of fenofibrate nanoparticles. Conclusions The combined usage of analytical surface methods provides the basis for a better understanding of phenomena that take place on drug surfaces. Such understanding is of importance for pharmaceutical development to achieve desirable quality attributes of nanosuspensions.
dc.description.urihttps://www.ncbi.nlm.nih.gov/pubmed/29468420
dc.language.isoen
dc.relation.ispartofPharmaceutical Research
dc.accessRightsAnonymous
dc.subjectatomic force microscopy
dc.subjectnanosuspension
dc.subjectsurface characterization
dc.subjectsurface dissolution
dc.subjectwet-milling
dc.titleTemperature-Induced Surface Effects on Drug Nanosuspensions
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.volume35
dc.issue69
dc.audienceScience
fhnw.publicationStatePublished
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandNo
fhnw.IsStudentsWorkno
fhnw.publicationOnlineJa


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