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dc.contributor.authorGaugler, Stephan
dc.contributor.authorRykl, Jana
dc.contributor.authorWagner, Irene
dc.contributor.authorvon Däniken, Tamara
dc.contributor.authorFingerhut, Ralph
dc.contributor.authorSchlotterbeck, Götz
dc.date.accessioned2018-12-13T09:57:33Z
dc.date.available2018-12-13T09:57:33Z
dc.date.issued2017-12
dc.identifier.doihttps://doi.org/10.3390/ijns4010002
dc.identifier.urihttp://hdl.handle.net/11654/26974
dc.description.abstractA new and fully automated newborn screening method for mass spectrometry was introduced in this paper. Pathological relevant amino acids, acylcarnitines, and certain steroids are detected within 4 min per sample. Each sample is treated in an automated and standardized workflow, where a mixture of deuterated internal standards is sprayed onto the sample before extraction. All compounds showed good linearity, and intra- and inter-day variation lies within the acceptance criteria (except for aspartic acid). The described workflow decreases analysis cost and labor while improving the sample traceability towards good laboratory practice.
dc.description.urihttps://www.mdpi.com/2409-515X/4/1/2
dc.language.isoen
dc.relation.ispartofInternational Journal of Neonatal Screening
dc.accessRightsAnonymous
dc.subjectnewborn screening (NBS)
dc.subjectdried blood spots (DBS)
dc.subjectautomation
dc.titleExtended and Fully Automated Newborn Screening Method for Mass Spectrometry Detection
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin
dc.volume4
dc.issue1
dc.audienceScience
fhnw.publicationStatePublished
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publication
fhnw.InventedHereYes
fhnw.PublishedSwitzerlandNo
fhnw.IsStudentsWorkno
fhnw.publicationOnlineJa


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