Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs – a PEARRL review
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[Aktualisierung auf Wunsch des Autors]
Autor:innen
Tsakiridou, Georgia
Koehl, Niklas
Price, Daniel
Ilie, Alexandra Roxana
Kalantzi, Lida
Kimpe, Kristof
Holm, Rene
Nair, Anita
Autor:in (Körperschaft)
Publikationsdatum
07/2018
Typ der Arbeit
Studiengang
Sammlung
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Journal of Pharmacy and Pharmacology
Themenheft
DOI der Originalpublikation
Reihe / Serie
Reihennummer
Jahrgang / Band
71
Ausgabe / Nummer
4
Seiten / Dauer
Patentnummer
Verlag / Herausgebende Institution
Wiley
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
Objectives
Solubility parameters have been used for decades in various scientific fields including pharmaceutics. It is, however, still a field of active research both on a conceptual and experimental level. This work addresses the need to review solubility parameter applications in pharmaceutics of poorly water‐soluble drugs.
Key findings
An overview of the different experimental and calculation methods to determine solubility parameters is provided, which covers from classical to modern approaches. In the pharmaceutical field, solubility parameters are primarily used to guide organic solvent selection, cocrystals and salt screening, lipid‐based delivery, solid dispersions and nano‐ or microparticulate drug delivery systems. Solubility parameters have been applied for a quantitative assessment of mixtures, or they are simply used to rank excipients for a given drug.
Summary
In particular, partial solubility parameters hold great promise for aiding the development of poorly soluble drug delivery systems. This is particularly true in early‐stage development, where compound availability and resources are limited. The experimental determination of solubility parameters has its merits despite being rather labour‐intensive because further data can be used to continuously improve in silico predictions. Such improvements will ensure that solubility parameters will also in future guide scientists in finding suitable drug formulations.
Schlagwörter
enabling formulation, in silico prediction, poorly water-soluble drug, solubility parameter
Fachgebiet (DDC)
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
0022-3573
2042-7158
2042-7158
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Lizenz
Zitation
JANKOVIC, Sandra, Georgia TSAKIRIDOU, Felix DITZINGER, Niklas KOEHL, Daniel PRICE, Alexandra Roxana ILIE, Lida KALANTZI, Kristof KIMPE, Rene HOLM, Anita NAIR, Brendan GRIFFIN, Christoph SAAL und Martin KUENTZ, 2018. Application of the solubility parameter concept to assist with oral delivery of poorly water-soluble drugs – a PEARRL review. Journal of Pharmacy and Pharmacology. Juli 2018. Bd. 71, Nr. 4. DOI 10.1111/jphp.12948. Verfügbar unter: https://doi.org/10.26041/fhnw-1640