Lipophilicity and hydrophobicity considerations in bio‐enabling oral formulations approaches – a PEARRL review
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Dateien
[Aktualisierung auf Wunsch des Autors]
Autor:innen
Price, Daniel
Ilie, Alexandra Roxana
Koehl, Niklas
Tsakiridou, Georgia
Aleandri, Simone
Kalantzi, Lida
Holm, Rene
Nair, Anita
Autor:in (Körperschaft)
Publikationsdatum
08/2018
Typ der Arbeit
Studiengang
Sammlung
Typ
01A - Beitrag in wissenschaftlicher Zeitschrift
Herausgeber:innen
Herausgeber:in (Körperschaft)
Betreuer:in
Übergeordnetes Werk
Journal of Pharmacy and Pharmacology
Themenheft
Reihe / Serie
Jahrgang / Band
71
Ausgabe / Nummer
Seiten / Dauer
Patentnummer
Verlag / Herausgebende Institution
Wiley
Verlagsort / Veranstaltungsort
Auflage
Version
Programmiersprache
Abtretungsempfänger:in
Praxispartner:in/Auftraggeber:in
Zusammenfassung
Objectives
This review highlights aspects of drug hydrophobicity and lipophilicity as determinants of different oral formulation approaches with specific focus on enabling formulation technologies. An overview is provided on appropriate formulation selection by focussing on the physicochemical properties of the drug.
Key findings
Crystal lattice energy and the octanol–water partitioning behaviour of a poorly soluble drug are conventionally viewed as characteristics of hydrophobicity and lipophilicity, which matter particularly for any dissolution process during manufacturing and regarding drug release in the gastrointestinal tract. Different oral formulation strategies are discussed in the present review, including lipid‐based delivery, amorphous solid dispersions, mesoporous silica, nanosuspensions and cyclodextrin formulations.
Summary
Current literature suggests that selection of formulation approaches in pharmaceutics is still highly dependent on the availability of technological expertise in a company or research group. Encouraging is that, recent advancements point to more structured and scientifically based development approaches. More research is still needed to better link physicochemical drug properties to pharmaceutical formulation design.
Schlagwörter
crystal lattice energy, hydrophobicity, lipophilicity, modern formulation approaches, poorly water-soluble drug
Fachgebiet (DDC)
Veranstaltung
Startdatum der Ausstellung
Enddatum der Ausstellung
Startdatum der Konferenz
Enddatum der Konferenz
Datum der letzten Prüfung
ISBN
ISSN
0022-3573
2042-7158
2042-7158
Sprache
Englisch
Während FHNW Zugehörigkeit erstellt
Ja
Publikationsstatus
Veröffentlicht
Begutachtung
Peer-Review der ganzen Publikation
Open Access-Status
Lizenz
Zitation
DITZINGER, Felix, Daniel PRICE, Alexandra Roxana ILIE, Niklas KOEHL, Sandra JANKOVIC, Georgia TSAKIRIDOU, Simone ALEANDRI, Lida KALANTZI, Rene HOLM, Anita NAIR, Christoph SAAL, Brendan GRIFFIN und Martin KUENTZ, 2018. Lipophilicity and hydrophobicity considerations in bio‐enabling oral formulations approaches – a PEARRL review. Journal of Pharmacy and Pharmacology. August 2018. Bd. 71. DOI /10.1111/jphp.12984. Verfügbar unter: https://doi.org/10.26041/fhnw-1641