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dc.contributor.authorAbreu-Villela, Renata
dc.contributor.authorKuentz, Martin
dc.date.accessioned2020-03-03T08:17:56Z
dc.date.available2020-03-03T08:17:56Z
dc.date.issued2019-09-06
dc.identifier.doi10.1007/s11095-019-2685-5
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/30640
dc.description.abstractPharmaceutical formulations are complex systems consisting of active pharmaceutical ingredient(s) and a number of excipients selected to provide the intended performance of the product. The understanding of materials' properties and technological processes is a requirement for building quality into pharmaceutical products. Such understanding is gained mostly from empirical correlations of material and process factors with quality attributes of the final product. However, it seems also important to gain knowledge based on mechanistic considerations. Promising is here to study morphological and/or topological characteristics of particles and their aggregates. These geometric aspects must be taken into account to better understand how product attributes emerge from raw materials, which includes, for example, mechanical tablet properties, disintegration or dissolution behavior. Regulatory agencies worldwide are promoting the use of physical models in pharmaceutics to design quality into a final product. This review deals with pharmaceutical applications of theoretical models, focusing on percolation theory, fractal, and multifractal geometry. The use of these so-called fractal approaches improves the understanding of different aspects in the development of solid dosage forms, for example by identifying critical drug and excipient concentrations, as well as to study effects of heterogeneity on dosage form performance. The aim is to link micro- and macrostructure to the emerging quality attributes of the pharmaceutical solid dosage forms as a strategy to enhance mechanistic understanding and to advance pharmaceutical development and manufacturing processes.en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pubmed/31493266en_US
dc.language.isoenen_US
dc.relation.ispartofPharmaceutical Researchen_US
dc.accessRightsAnonymous*
dc.subjectfractal geometryen_US
dc.subjectfractal-like kineticsen_US
dc.subjectgeometric distributionen_US
dc.subjectpercolation theoryen_US
dc.subjectsolid dosage formsen_US
dc.titleBenefits of Fractal Approaches in Solid Dosage Form Developmenten_US
dc.type01 - Zeitschriftenartikel, Journalartikel oder Magazin*
dc.volume36en_US
dc.issue11en_US
dc.audienceScienceen_US
fhnw.publicationStatePublisheden_US
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publicationen_US
fhnw.InventedHereYesen_US
fhnw.PublishedSwitzerlandYesen_US
fhnw.pagination156en_US
fhnw.IsStudentsWorknoen_US
fhnw.publicationOnlineJaen_US


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