Towards a novel cost-effective and versatile bioink for 3D-bioprinting in tissue engineering

dc.accessRightsAnonymous*
dc.contributor.authorZüger, Fabian
dc.contributor.authorBerner, Natascha
dc.contributor.authorGullo, Maurizio
dc.date.accessioned2023-04-19T12:00:42Z
dc.date.available2023-04-19T12:00:42Z
dc.date.issued2023-01-09
dc.description.abstract3D-bioprinting for tissue regeneration relies on, among other things, hydrogels with favorable rheological properties. These include shear thinning for cell-friendly extrusion, post-printing structural stability as well as physiologically relevant elastic moduli needed for optimal cell attachment, proliferation, differentiation and tissue maturation. This work introduces a cost-efficient gelatin-methylcellulose based hydrogel whose rheological properties can be independently optimized for optimal printability and tissue engineering. Hydrogel viscosities were designed to present three different temperature regimes: low viscosity for eased cell suspension and printing with minimal shear stress, form fidelity directly after printing and long term structural stability during incubation. Enzymatically crosslinked hydrogel scaffolds with stiffnesses ranging from 5 to 50 kPa were produced, enabling the hydrogel to biomimic cell environments for different types of tissues. The bioink showed high intrinsic cytocompatibility and tissues fabricated by embedding and bioprinting NIH 3T3 fibroblasts showed satisfactory viability. This novel hydrogel uses robust and inexpensive technology, which can be adjusted for implementation in tissue regeneration, e.g., in myocardial or neural tissue engineering.en_US
dc.identifier.doi10.3390/biomimetics8010027
dc.identifier.issn2313-7673
dc.identifier.urihttps://irf.fhnw.ch/handle/11654/34872.1
dc.issue1en_US
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofBiomimeticsen_US
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en_US
dc.subject.ddc600 - Technik, Medizin, angewandte Wissenschaftenen_US
dc.titleTowards a novel cost-effective and versatile bioink for 3D-bioprinting in tissue engineeringen_US
dc.type01A - Beitrag in wissenschaftlicher Zeitschrift*
dc.volume8en_US
fhnw.InventedHereYesen_US
fhnw.IsStudentsWorknoen_US
fhnw.ReviewTypeAnonymous ex ante peer review of a complete publicationen_US
fhnw.openAccessCategoryGold
fhnw.publicationStatePublisheden_US
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