Institut für Medizintechnik und Medizininformatik
Dauerhafte URI für die Sammlunghttps://irf.fhnw.ch/handle/11654/23
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32 Ergebnisse
Ergebnisse nach Hochschule und Institut
Publikation Single-molecule real-time sequencing of the M protein.Toward personalized medicine in monoclonal gammopathies(Wiley, 05.08.2022) Cascino, Pasquale; Nevone, Alice; Piscitelli, Maggie; Scopelliti, Claudia; Girelli, Maria; Mazzini, Giulia; Caminito, Serena; Russo, Giancarlo; Milani, Paolo; Basset, Marco; Foli, Andrea; Fazio, Francesca; Casarini, Simona; Massa, Margherita; Bozzola, Margherita; Ripepi, Jessica; Sesta, Melania Antonietta; Acquafredda, Gloria; De Cicco, Marica; Moretta, Antonia; Rognoni, Paola; Milan, Enrico; Ricagno, Stefano; Lavatelli, Francesca; Petrucci, Maria Teresa; Miho, Enkelejda; Klersy, Catherine; Merlini, Giampaolo; Palladini, Giovanni; Nuvolone, Mario01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Unconstrained generation of synthetic antibody–antigen structures to guide machine learning methodology for antibody specificity prediction(Nature, 19.12.2022) Robert, Philippe A.; Akbar, Rahmad; Frank, Robert; Pavlović, Milena; Widrich, Michael; Snapkov, Igor; Slabodkin, Andrei; Chernigovskaya, Maria; Scheffer, Lonneke; Smorodina, Eva; Rawat, Puneet; Mehta, Brij Bhushan; Vu, Mai Ha; Mathisen, Ingvild Frøberg; Prósz, Aurél; Abram, Krzysztof; Olar, Alex; Miho, Enkelejda; Haug, Dag Trygve Tryslew; Lund-Johansen, Fridtjof; Hochreiter, Sepp; Haff, Ingrid Hobæk; Klambauer, Günter; Sandve, Geir Kjetil; Greiff, VictorMachine learning (ML) is a key technology for accurate prediction of antibody–antigen binding. Two orthogonal problems hinder the application of ML to antibody-specificity prediction and the benchmarking thereof: the lack of a unified ML formalization of immunological antibody-specificity prediction problems and the unavailability of large-scale synthetic datasets to benchmark real-world relevant ML methods and dataset design. Here we developed the Absolut! software suite that enables parameter-based unconstrained generation of synthetic lattice-based three-dimensional antibody–antigen-binding structures with ground-truth access to conformational paratope, epitope and affinity. We formalized common immunological antibody-specificity prediction problems as ML tasks and confirmed that for both sequence- and structure-based tasks, accuracy-based rankings of ML methods trained on experimental data hold for ML methods trained on Absolut!-generated data. The Absolut! framework has the potential to enable real-world relevant development and benchmarking of ML strategies for biotherapeutics design.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Geometric cuts by an autonomous laser osteotome increase stability in mandibular reconstruction with free fibula grafts. A cadaver study(Elsevier, 2024) Gottsauner, Maximilian; Morawska, Marta M.; Tempel, Simon; Müller-Gerbl, Magdalena; Dalcanale, Federico; de Wild, Michael; Ettl, TobiasBackground Nonunion and plate exposure represent a major complication after mandibular reconstruction with free fibula flaps. These drawbacks may be resolved by geometric osteotomies increasing intersegmental bone contact area and stability. Purpose The aim of this study was to compare intersegmental bone contact and stability of geometric osteotomies to straight osteotomies in mandibular reconstructions with free fibula grafts performed by robot-guided erbium-doped yttrium aluminum garnet laser osteotomy.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Geometric cuts by an autonomous laser osteotome increase stability in mandibular reconstruction with free fibula grafts. A cadaver study(Elsevier, 2024) Gottsauner, Maximilian; Morawska, Marta M.; Tempel, Simon; Müller-Gerbl, Magdalena; Dalcanale, Federico; de Wild, Michael; Ettl, Tobias01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Low-coercivity perpendicular spin transfer torque magnetic tunnel junctions as nanoscale magnetic sensors(IEEE, 09/2023) Nicolas, Hugo; Sousa, Ricardo C.; Mora-Hernández, Ariam; Prejbeanu, Ioan-Lucian; Hebrard, Luc; Kammerer, Jean-Baptiste; Pascal, JorisThis paper presents the use of the spin transfer torque effect in perpendicular magnetic tunnel junctions to operate the devices as magnetic sensors. The junctions, specifically designed for sensing applications exhibit close to low-coercivity, allowing the sensitivity to be as high as 25 mV/mT for a large dynamic range of 20 mT. In addition, the junctions have diameters ranging from 20 to 100 nanometers, making them among the smallest magnetic sensing elements ever reported to our knowledge. A single operational amplifier operates the junction and outputs a voltage proportional to the external magnetic field. This paper opens the way to a monolithic integration of both the conditioning electronics and the perpendicular magnetic tunnel junction.04B - Beitrag KonferenzschriftPublikation Conditioning circuits for nanoscale perpendicular spin transfer torque magnetic tunnel junctions as magnetic sensors(IEEE, 2023) Nicolas, Hugo; Sousa, Ricardo C.; Mora-Hernández, Ariam; Prejbeanu, Ioan-Lucian; Hebrard, Luc; Kammerer, Jean-Baptiste; Pascal, JorisThis article demonstrates a new type of magnetic sensor using a perpendicular spin transfer torque magnetic tunnel junction (MTJ). The sensing element has a cylindrical shape of 50 nm in diameter and is to our knowledge among the smallest magnetic sensor ever reported. This article describes the principle of operation of the sensing element and the associated signal processing electronics, which delivers a signal proportional to the external magnetic field. Experimental results are detailed and compared to the state-of-the-art commercially available integrated magnetic sensors as well as published magnetoresistive sensors based on MTJs with comparable size. The measured sensitivity of the developed sensor is 1.28 V/T, and its dynamic range reaches 80 mT. The measured noise level is 21.8μT/√ Hz. Two different operating principles of the proposed sensor are described and compared, one based on a time-to-digital converter and one based on a pulsewidth-modulated (PWM) signal. Both methods require only standard microelectronics components, which are suitable for monolithic integration of the sensing element with its conditioning electronics. Subsequent improvements of the sensing element as well as conditioning electronics are required to further lower the noise level. The sensing element and its conditioning electronics are compatible with fabrication processes already used in magnetic random access memory fabrication. This opens the way to mass production and addresses various markets, such as consumer electronics, automotive, industrial sensing, physics experiments, or medical devices.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Towards a new generation of electromagnetic navigation system for deep brain stimulation(European Society for Stereotactic and Functional Neurosurgery, 2023) Vergne, Céline; Morgan, Madec; Guzmann, Raphael; Pascal, Joris; Hemm-Ode, Simone06 - PräsentationPublikation Tracking of a magnetically navigated millirobot with a magnetic-field camera(IEEE, 10.04.2024) Vergne, Céline; Pinto Inácio, José Miguel; Quirin, Thomas; Sargent, David; Madec, Morgan; Pascal, JorisA significant progress has been made in the development of magnetic micromanipulation for minimally invasive surgery. The development of systems to localize millimeter-sized robots during magnetic manipulation without line-of-sight detection remains, however, a challenging task. In this study, we focused on the development of a tracking system aiming to fill this gap. A robot, which consists of a cylindrical magnet of 1-mm diameter, is localized using a 2-D array of 3-D magnetoresistive sensors. The system, also called magnetic-field camera (MFC), provides tracking of the robot with a refresh rate of 2 Hz. The developed tracking algorithm reaches a mean absolute error (MAE) for the position and the orientation of, respectively, 0.56 mm and 5.13° in 2-D. This system can be added to the existing magnetic manipulation systems (MMSs) allowing closed-loop control of the navigation. The performances of the MFC are not affected by an exposure to strong magnetic fields. Exposures up to 3 T have been validated. Increasing the integrability of the MFC into MMSs. The presented tracking system makes it possible to target applications, such as minimally invasive eye surgery or drug delivery. The high spatial and magnetic resolutions allow the tracking of magnetic particles, down to 200- μm diameter, when placed close to the surface. The system could also be suitable for the localization of small objects for 2-D biomanipulation.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Intracoronary ECG ST-segment shift remission time during reactive coronary hyperemia (tau-icECG): a new approach to assess hemodynamic coronary stenosis severity(Oxford University Press, 2023) Kieninger-Graefitsch, Andrea; Bigler, Marius Reto; Waldmann, Frédéric; Wildhaber, Reto; Seiler, ChristianCoronary pressure-derived fractional flow reserve (FFR) measurements are recommended for hemodynamic coronary stenosis assessment. Given temporary paralysis of the coronary microcirculation during hyperemia, pressure is, in theory, directly related to coronary flow. Pressure drop during hyperemia across a coronary stenosis, thus, provides an estimate of its restrictive effect on flow. FFR during reactive hyperemia induced by a proximal, 1-minute coronary artery balloon occlusion has been shown non-inferior to FFR as obtained by adenosine-induced hyperemia. Intracoronary ECG (icECG) is more sensitive in detecting myocardial ischemia than the surface ECG, and can be easily obtained.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Technical characterization of single-lead ECG signals from 4 different smartwatches and its potential clinical implications(Elsevier, 2023) Knecht, Sven; Waldmann, Frédéric; Kuhn, Raffael; Mannhart, Diego; Kühne, Michael; Sticherling, Christian; Badertscher, Patrick; Wildhaber, Reto01A - Beitrag in wissenschaftlicher Zeitschrift