Institut für Medizintechnik und Medizininformatik

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  • Publikation
    Experimental assessment of the performances of an anisotropic magnetoresistive sensor after exposure to strong magnetic fields
    (IEEE, 2023) Vergne, Céline; Nicolas, Hugo; Madec, Morgan; Hemm-Ode, Simone; Guzman, Raphael; Pascal, Joris [in: 2023 IEEE International Magnetic Conference - Short Papers (INTERMAG Short Papers)]
    On-chip magnetometers are already integrated within long-term implants such as cardiac implantable electronic devices. They are also good candidates to be integrated within the next generations of brain stimulation electrodes to provide their position and orientation. In all cases, long-term implants are expected to be at least certified as MRI conditional. We investigated the resilience to the exposure to 3 T and 7 T of an anisotropic magnetoresistive sensor integrating a set/reset function. The sensitivity, non-linearity, and offset of a batch of 63 identical sensors were not affected by the exposure. These preliminary results provide new insights on the usability of magnetoresistive sensors for biomedical applications requiring MRI conditionality.
    04B - Beitrag Konferenzschrift
  • Publikation
    Three-dimensional printed hydroxyapatite bone substitutes designed by a novel periodic minimal surface algorithm are highly osteoconductive
    (Liebert, 2023) Maevskaia, Ekaterina; Khera, Nupur; Ghayor, Chafik; Bhattacharya, Indranil; Guerrero, Julien; Nicholls, Flora; Waldvogel, Christian; Bärtschi, Ralph; Fritschi, Lea; Salamon, Dániel; Özcan, Mutlu; Malgaroli, Patrick; Seiler, Daniel; de Wild, Michael; Weber, Franz E. [in: 3D Printing and Additive Manufacturing]
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Publikation
    3D-printed LEGO®-inspired titanium scaffolds for patient-specific regenerative medicine
    (Elsevier, 2023) Lee, Seunghun S.; Du, Xiaoyu; Smit, Thijs; Bissacco, Elisa G.; Seiler, Daniel; de Wild, Michael; Ferguson, Stephen J. [in: Biomaterials Advances]
    Despite the recent advances in 3D-printing, it is often difficult to fabricate implants that optimally fit a defect size or shape. There are some approaches to resolve this issue, such as patient-specific implant/scaffold designs based on CT images of the patients, however, this process is labor-intensive and costly. Especially in developing countries, affordable treatment options are required, while still not excluding these patient groups from potential material and manufacturing advances. Here, a selective laser melting (SLM) 3D-printing strategy was used to fabricate a hierarchical, LEGO®-inspired Assemblable Titanium Scaffold (ATS) system, which can be manually assembled in any shape or size with ease. A surgeon can quickly create a scaffold that would fit to the defect right before the implantation during the surgery. Additionally, the direct inclusion of micro- and macroporous structures via 3D-printing, as well as a double acid-etched surface treatment (ST) in the ATS, ensure biocompatibility, sufficient nutrient flow, cell migration and enhanced osteogenesis. Three different structures were designed (non-porous:NP, semi-porous:SP, ultra-porous:UP), 3D-printed with the SLM technique and then surface treated for the ST groups. After analyzing characteristics of the ATS such as printing quality, surface roughness and interconnected porosity, mechanical testing and finite element analysis (FEA) demonstrated that individual and stacked ATS have sufficient mechanical properties to withstand loading in a physiological system. All ATS showed high cell viability, and the SP and UP groups demonstrated enhanced cell proliferation rates compared to the NP group. Furthermore, we also verified that cells were well-attached and spread on the porous structures and successful cell migration between the ATS units was seen in the case of assemblies. The UP and SP groups exhibited higher calcium deposition and RT-qPCR proved higher osteogenic gene expression compared to NP group. Finally, we demonstrate a number of possible medical applications that reveal the potential of the ATS through assembly. © 2023 The Authors
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Publikation
    Real-time feature extraction from electrocochleography with impedance measurements during cochlear implantation using linear state-space models
    (IEEE, 2023) Andonie, Raphael R.; Wimmer, Wilhelm; Wildhaber, Reto; Caversaccio, Marco; Weder, Stefan [in: IEEE Transactions on Biomedical Engineering]
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Publikation
    Solving the explainable AI conundrum by bridging clinicians’ needs and developers’ goals
    (Nature, 22.05.2023) Bienefeld, Nadine; Boss, Jens Michael; Lüthy, Rahel; Brodbeck, Dominique; Azzati, Jan; Blaser, Mirco; Willms, Jan; Keller, Emanuela [in: npj Digital Medicine]
    Explainable artificial intelligence (XAI) has emerged as a promising solution for addressing the implementation challenges of AI/ML in healthcare. However, little is known about how developers and clinicians interpret XAI and what conflicting goals and requirements they may have. This paper presents the findings of a longitudinal multi-method study involving 112 developers and clinicians co-designing an XAI solution for a clinical decision support system. Our study identifies three key differences between developer and clinician mental models of XAI, including opposing goals (model interpretability vs. clinical plausibility), different sources of truth (data vs. patient), and the role of exploring new vs. exploiting old knowledge. Based on our findings, we propose design solutions that can help address the XAI conundrum in healthcare, including the use of causal inference models, personalized explanations, and ambidexterity between exploration and exploitation mindsets. Our study highlights the importance of considering the perspectives of both developers and clinicians in the design of XAI systems and provides practical recommendations for improving the effectiveness and usability of XAI in healthcare.
    01A - Beitrag in wissenschaftlicher Zeitschrift