Institut für Medizintechnik und Medizininformatik
Dauerhafte URI für die Sammlunghttps://irf.fhnw.ch/handle/11654/23
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16 Ergebnisse
Ergebnisse nach Hochschule und Institut
Publikation Miniaturization of stent prototypes by µSLM(Hochschule für Life Sciences FHNW, 2024) Wasmer, Larissa; de Wild, Michael; Seiler, Daniel; Politecnico di Torino11 - Studentische ArbeitPublikation Atlas-Based Segmentation Algorithm(Hochschule für Life Sciences FHNW, 2024) Kohler, Roger; Vogel, Dorian; Linköpings Universitet11 - Studentische ArbeitPublikation Quantitative assessment of repetitive lower limb movements used in the MDS-UPDRS-III scale in healthy subjects(Hochschule für Life Sciences FHNW, 2024) Hunziker, Sven; Hemm-Ode, Simone; Vogel, Dorian; Kalt, Denise; Kantonsspital Baden AG, Baden AG11 - Studentische ArbeitPublikation Robustness comparison of optimization techniques in Intensity Modulated Proton Therapy (IMPT)(Hochschule für Life Sciences FHNW, 2024) Hagmann, Virgile; Knopf, Antje; Paul Scherrer Institut, Villigen11 - Studentische ArbeitPublikation Stimmanalyse zur Evaluierung des Leidens bei Patienten mit Krebs(Hochschule für Life Sciences FHNW, 2024) Dere, Türkmen; Hemm-Ode, Simone; Kantonsspital Baselland, Liestal; Palliativzentrum Hildegard, Basel11 - Studentische ArbeitPublikation Analysis of Patient Reported Outcome Measures (PROMs)(Hochschule für Life Sciences FHNW, 2024) Schlumpf, Oliver; Kahraman, Abdullah; Luzerner Kantonsspital (LUKS); Swiss Sarcoma Network (SSN)11 - Studentische ArbeitPublikation Investigation of different quality assessment procedures for fast and reliable validation of CBCT-based synthetic CTs(Hochschule für Life Sciences FHNW, 2024) Maurenbrecher, Joakim; Knopf, Antje; Paul Scherrer Institut, Villigen11 - Studentische ArbeitPublikation Maturation of the human immunoglobulin heavy chain repertoire with age(Frontiers Research Foundation, 06.08.2020) Ghraichy, Marie; Galson, Jacob D.; Kovaltsuk, Aleksandr; von Niederhäusern, Valentin; Pachlopnik Schmid, Jana; Recher, Mike; Jauch, Annaïse J.; Miho, Enkelejda; Kelly, Dominic F.; Deane, Charlotte M.; Trück, JohannesB cells play a central role in adaptive immune processes, mainly through the production of antibodies. The maturation of the B cell system with age is poorly studied. We extensively investigated age-related alterations of naïve and antigen-experienced immunoglobulin heavy chain (IgH) repertoires. The most significant changes were observed in the first 10 years of life, and were characterized by altered immunoglobulin gene usage and an increased frequency of mutated antibodies structurally diverging from their germline precursors. Older age was associated with an increased usage of downstream IgH constant region genes and fewer antibodies with self-reactive properties. As mutations accumulated with age, the frequency of germline-encoded self-reactive antibodies decreased, indicating a possible beneficial role of self-reactive B cells in the developing immune system. Our results suggest a continuous process of change through childhood across a broad range of parameters characterizing IgH repertoires and stress the importance of using well-selected, age-appropriate controls in IgH studies.01A - Beitrag in wissenschaftlicher ZeitschriftPublikation A survey of practice patterns for real-time intrafractional motion-management in particle therapy(Elsevier, 26.04.2023) Zhang, Ye; Trnkova, Petra; Toshito, Toshiyuki; Heijmen, Ben; Richter, Christian; Aznar, Marianne; Albertini, Francesca; Bolsi, Alexandra; Daartz, Juliane; Bertholet, Jenny; Knopf, Antje01A - Beitrag in wissenschaftlicher ZeitschriftPublikation Increased construct stiffness with meniscal repair sutures and devices increases the risk of cheese-wiring during biomechanical load-to-failure testing(SAGE, 15.06.2021) Müller, Sebastian; Schwenk, Tanja; de Wild, Michael; Dimitrou, Dimitris; Rosso, ClaudioBackground: Cheese-wiring, the suture that cuts through the meniscus, is a well-known issue in meniscal repair. So far, contributing factors are neither fully understood nor sufficiently studied. Hypothesis/purpose: To investigate whether the construct stiffness of repair sutures and devices correlates with suture cut-through (cheese-wiring) during load-to-failure testing. Study design: Controlled laboratory study. Methods: In 131 porcine menisci, longitudinal bucket-handle tears were repaired using either inside-out sutures (n = 66; No. 0 Ultrabraid, 2-0 Orthocord, 2-0 FiberWire, and 2-0 Ethibond) or all-inside devices (n = 65; FastFix360, Omnispan, and Meniscal Cinch). After cyclic loading, load-to-failure testing was performed. The mode of failure and construct stiffness were recorded. A receiver operating characteristic curve analysis was performed to define the optimal stiffness threshold for predicting meniscal repair failure by cheese-wiring. The 2-tailed t test and analysis of variance were used to test significance. Results: Loss of suture fixation was the most common mode of failure in all specimens (58%), except for the Omnispan, which failed most commonly because of anchor pull-through. The Omnispan demonstrated the highest construct stiffness (30.8 ± 3.5 N/mm), whereas the Meniscal Cinch (18.0 ± 8.8 N/mm) and Ethibond (19.4 ± 7.8 N/mm) demonstrated the lowest construct stiffness. The Omnispan showed significantly higher stiffness compared with the Meniscal Cinch (P < .001) and Ethibond (P = .02), whereas the stiffness of the Meniscal Cinch was significantly lower compared with that of the FiberWire (P = .01), Ultrabraid (P = .04), and FastFix360 (P = .03). While meniscal repair with a high construct stiffness more often failed by cheese-wiring, meniscal repair with a lower stiffness failed by loss of suture fixation, knot slippage, or anchor pull-through. Meniscal repair with a stiffness >26.5 N/mm had a 3.6 times higher risk of failure due to cheese-wiring during load-to-failure testing (95% CI, 1.4-8.2; P < .0001). Conclusion: Meniscal repair using inside-out sutures and all-inside devices with a higher construct stiffness (>26.5 N/mm) was more likely to fail through suture cut-through (cheese-wiring) than that with a lower stiffness (≤26.5 N/mm). Clinical relevance: This is the first study investigating the impact of construct stiffness on meniscal repair failure by suture cut-through (cheese-wiring).01A - Beitrag in wissenschaftlicher Zeitschrift