Bayer-Oglesby, Lucy

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Bayer-Oglesby
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Lucy
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Bayer-Oglesby, Lucy

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  • Publikation
    Living near main streets and respiratory symptoms in adults. the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults
    (Oxford University Press, 10.10.2006) Bayer-Oglesby, Lucy; Schindler, Christian; Hazenkamp-von Arx, Marianne E.; Braun-Fahrländer, Charlotte; Keidel, Dirk; Rapp, Regula; Künzli, Nino; Braendli, Otto; Burdet, Luc; Sally Liu, L-J; Leuenberger, Philippe; Ackermann-Liebrich, Ursula [in: American Journal of Epidemiology]
    The Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA), conducted in 1991 (SAPALDIA 1) in eight areas among 9,651 randomly selected adults aged 18-60 years, reported associations among the prevalence of respiratory symptoms, nitrogen dioxide, and particles with an aerodynamic diameter of less than 10 microg/m3. Later, 8,047 subjects reenrolled in 2002 (SAPALDIA 2). The effects of individually assigned traffic exposures on reported respiratory symptoms were estimated, while controlling for socioeconomic and exposure- and health-related factors. The risk of attacks of breathlessness increased for all subjects by 13% (95% confidence interval: 3, 24) per 500-m increment in the length of main street segments within 200 m of the home and decreased in never smokers by 12% (95% confidence interval: 0, 22) per 100-m increment in distance from home to a main street. Living within 20 m of a main street increased the risks of regular phlegm by 15% (95% confidence interval: 0, 31) and wheezing with breathing problems by 34% (95% confidence interval: 0, 79) in never smokers. In 2002, the effects related to road distance were different from those in 1991, which could be due to changes in the traffic pollution mixture. These findings among a general population provide strong confirmation that living near busy streets leads to adverse respiratory health effects.
    01A - Beitrag in wissenschaftlicher Zeitschrift
  • Publikation
    Single pollutant versus surrogate measure approaches: Do single pollutant risk assessments underestimate the impact of air pollution on lung cancer risk?
    (Lippincott Williams & Wilkins, 2003) Röösli, Martin; Künzli, Nino; Schindler, Christian; Theis, Gaston; Bayer-Oglesby, Lucy; Mathys, Patrick; Camenzind, Markus; Braun-Fahrländer, Charlotte [in: Journal of Occupational and Environmental Medicine]
    Cancer risk as a result of air pollution may be quantified by different approaches. We compared the sum of unit risk based effects of single pollutants with an epidemiology-based method by using PM10 as a surrogate of the total air pollution. The excess rate for lung cancer cases attributable to an increase of 10 μg/m3 in average PM10 exposure was estimated from available cohort studies. Applying the epidemiology-based risk method to the air pollution situation in the Basel area (Switzerland) resulted in 13.3 (95% CI = 6.9–19.8) excess lung cancer cases per 100,000 person years. This estimate was considerably higher than the unit risk-based estimate yielding 1.1 (range, 0.45–2.8) cancer cases per 100,000 person years. We discuss these discrepancies in light of inherent differences between approaches in toxicology and epidemiology.
    01A - Beitrag in wissenschaftlicher Zeitschrift