Single pollutant versus surrogate measure approaches: Do single pollutant risk assessments underestimate the impact of air pollution on lung cancer risk?
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Author (Corporation)
Publication date
2003
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01A - Journal article
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Journal of Occupational and Environmental Medicine
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Volume
45
Issue / Number
7
Pages / Duration
715-723
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Lippincott Williams & Wilkins
Place of publication / Event location
Philadelphia
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Abstract
Cancer risk as a result of air pollution may be quantified by different approaches. We compared the sum of unit risk based effects of single pollutants with an epidemiology-based method by using PM10 as a surrogate of the total air pollution. The excess rate for lung cancer cases attributable to an increase of 10 μg/m3 in average PM10 exposure was estimated from available cohort studies. Applying the epidemiology-based risk method to the air pollution situation in the Basel area (Switzerland) resulted in 13.3 (95% CI = 6.9–19.8) excess lung cancer cases per 100,000 person years. This estimate was considerably higher than the unit risk-based estimate yielding 1.1 (range, 0.45–2.8) cancer cases per 100,000 person years. We discuss these discrepancies in light of inherent differences between approaches in toxicology and epidemiology.
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1076-2752
Language
English
Created during FHNW affiliation
No
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Published
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Closed
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Citation
Röösli, M., Künzli, N., Schindler, C., Theis, G., Bayer-Oglesby, L., Mathys, P., Camenzind, M., & Braun-Fahrländer, C. (2003). Single pollutant versus surrogate measure approaches: Do single pollutant risk assessments underestimate the impact of air pollution on lung cancer risk? Journal of Occupational and Environmental Medicine, 45(7), 715–723. https://doi.org/10.1097/01.jom.0000079082.33909.c2