Schlotterbeck, Götz
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Schlotterbeck, Götz
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- PublikationExtended and Fully Automated Newborn Screening Method for Mass Spectrometry Detection(MDPI, 12/2017) Gaugler, Stephan; Rykl, Jana; Wagner, Irene; von Däniken, Tamara; Fingerhut, Ralph; Schlotterbeck, Götz [in: International Journal of Neonatal Screening]A new and fully automated newborn screening method for mass spectrometry was introduced in this paper. Pathological relevant amino acids, acylcarnitines, and certain steroids are detected within 4 min per sample. Each sample is treated in an automated and standardized workflow, where a mixture of deuterated internal standards is sprayed onto the sample before extraction. All compounds showed good linearity, and intra- and inter-day variation lies within the acceptance criteria (except for aspartic acid). The described workflow decreases analysis cost and labor while improving the sample traceability towards good laboratory practice.01A - Beitrag in wissenschaftlicher Zeitschrift