Schuler, Felix
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Schuler, Felix
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- PublikationLattice Microarchitecture for Bone Tissue Engineering from Calcium Phosphate Compared to Titanium(Mary Ann Liebert, 10/2018) Chen, Tse-Hsiang; Ghayor, Chafik; Siegenthaler, Barbara; Schuler, Felix; Rüegg, Jasmine; de Wild, Michael; Weber, Franz E. [in: Tissue Engineering. Part A]Additive manufacturing of bone tissue engineering scaffolds will become a key element for personalized bone tissue engineering in the near future. Several additive manufacturing processes are based on extrusion where the deposition of the filament will result in a three-dimensional lattice structure. Recently, we studied diverse lattice structures for bone tissue engineering realized by laser sintering of titanium. In this work, we used lithography-based ceramic manufacturing of lattice structures to produce scaffolds from tricalcium phosphates (TCP) and compared them in vivo to congruent titanium scaffolds manufactured with the identical computer-aided design data to look for material-based differences in bony healing. The results show that, during a 4-week period in a noncritical-size defect in a rabbit calvarium, both scaffolds with the identical microarchitecture performed equally well in terms of bony regeneration and bony bridging of the defect. A significant increase in both parameters could only be achieved when the TCP-based scaffolds were doped with bone morphogenetic protein-2. In a critical-size defect in the calvarial bone of rabbits, however, the titanium scaffold performed significantly better than the TCP-based scaffold, most likely due to its higher mechanical stability. We conclude that titanium and TCP-based scaffolds of the same microarchitecture perform equally well in terms of bone regeneration, provided the microarchitecture meets the mechanical demand at the site of implantation.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationOsteoconductive Lattice Microarchitecture for Optimized Bone Regeneration(Mary Ann Liebert, 06/2018) de Wild, Michael; Ghayor, Chafik; Zimmermann, Simon; Rüegg, Jasmine; Nicholls, Flora; Schuler, Felix; Chen, Tse-Hsiang; Weber, Franz E. [in: 3D Printing and Additive Manufacturing]Selective laser melting (SLM) is one methodology to realize additive manufacturing and is mainly used to join metal powder in a layer-by-layer manner to produce a solid three-dimensional (3D) object. For bone tissue engineering purposes, scaffolds can readily be designed as 3D data model and realized with titanium known for its excellent osseointegration behavior. The microarchitecture, that is, design with submillimeter features, of additively manufactured scaffolds is in many cases a lattice structure. This study aimed to apply SLM that allows a high degree of microarchitectural freedom to generate lattice structures and to determine the optimal distance between rods and the optimal diameter of rods for osteoconduction (bone ingrowth into scaffolds) and bone regeneration. For the biological readout, diverse SLM-fabricated titanium implants were placed in the calvarium of rabbits and new bone formation and defect bridging were determined after 4 weeks of healing. The results from the middle section of the defects show that with a lattice microarchitecture, the optimal distance between titanium rods is around 0.8 mm and the optimal rod dimension is between 0.3 and 0.4 mm to optimize defect bridging and bone regeneration.01A - Beitrag in wissenschaftlicher Zeitschrift
- PublikationPre-process calculation to optimize laser parameter in selective laser melting(2018) Matter, Nathalie; Schuler, Felix; Schumacher, Ralf; de Wild, Michael [in: SSB+RM Conference Abstracts]04B - Beitrag Konferenzschrift
- Publikation3D-printed auxetic structures for bio-medical application(2018) Schuler, Felix; Renaud, Pascal; de Wild, Michael [in: Swiss Society for Biomaterials and Regenerative Medicine]04B - Beitrag Konferenzschrift
- PublikationBiopsy needle drive actuators made from NiTi(2017) Schuler, Felix; Renaud, Pascal; de Wild, Michael06 - Präsentation