2020-04-25, Vogel, Dorian, Shah, Ashesh, Hemm-Ode, Simone

Deep brain stimulation (DBS) therapy requires extensive patient-specific planning prior to implantation to achieve optimal clinical outcomes. Collective analysis of patient’s brain images is promising in order to provide more systematic planning assistance. In this paper the design of a normalization pipeline using a group specific multi-modality iterative template creation process is presented. The focus was to compare the performance of a selection of freely available registration tools and select the best combination. The workflow was applied on 19 DBS patients with T1 and WAIR modality images available. Non-linear registrations were computed with ANTS, FNIRT and DRAMMS, using several settings from the literature. Registration accuracy was measured using single-expert labels of thalamic and subthalamic structures and their agreement across the group. The best performance was provided by ANTS using the High Variance settings published elsewhere. Neither FNIRT nor DRAMMS reached the level of performance of ANTS. The resulting normalized definition of anatomical structures were used to propose an atlas of the diencephalon region defining 58 structures using data from 19 patients.

2016-11-25, Hemm-Ode, Simone, Pison, Daniela, Alonso, Fabiola, Shah, Ashesh, Coste, Jérôme, Lemaire, Jean-Jaques, Wårdell, Karin

2016-08, Shah, Ashesh, Alonso, Fabiola, Lemaire, Jean-Jaques, Pison, Daniela, Wardell, Karin, Coste, Jérôme, Schkommodau, Erik, Hemm-Ode, Simone

2016, Shah, Ashesh, Coste, Jérôme, Lemaire, Jean-Jaques, Taub, Ethan, Schüpbach, W.M. Michael, Pollo, Claudio, Schkommodau, Erik, Guzman, Raphael, Hemm-Ode, Simone

Deep brain stimulation (DBS) surgery is extensively used in the treatment of movement disorders. Nevertheless, methods to evaluate the clinical response during intraoperative stimulation tests to identify the optimal position for the implantation of the chronic DBS lead remain subjective. In this paper, we describe a new, versatile method for quantitative intraoperative evaluation of improvement in tremor with an acceleration sensor that is mounted on the patient’s wrist during surgery. At each anatomical test position, the improvement in tremor compared to the initial tremor is estimated on the basis of extracted outcome measures. This method was tested on 15 tremor patients undergoing DBS surgery in two centers. Data from 359 stimulation tests were acquired. Our results suggest that accelerometric evaluation detects tremor changes more sensitively than subjective visual ratings. The effective stimulation current amplitudes identified from the quantitative data (1.1 ± 0.8 mA) are lower than those identified by visual evaluation (1.7 ± 0.8 mA) for similar improvement in tremor. Additionally, if these data had been used to choose the chronic implant position of the DBS lead, 15 of the 26 choices would have been different. These results show that our method of accelerometric evaluation can potentially improve DBS targeting.

2020-01-30, Shah, Ashesh, Vogel, Dorian, Pison, Daniela, Schkommodau, Erik, Hemm-Ode, Simone

2016-09, Shah, Ashesh, Alonso, Fabiola, Lemaire, Jean-Jaques, Wardell, Karin, Pison, Daniela, Coste, Jérôme, Schkommodau, Erik, Hemm-Ode, Simone

2016, Shah, Ashesh, Alonso, Fabiola, Pison, Daniela, Lemaire, Jean-Jaques, Wårdell, Karin, Coste, Jérôme, Schkommodau, Erik, Hemm-Ode, Simone

2017-09, Shah, Ashesh, Coste, Jérôme, Lemaire, Jean-Jaques, Schkommodau, Erik, Taub, Ethan, Guzman, Raphael, Hemm-Ode, Simone

2016-09, Shah, Ashesh, Coste, Jérôme, Lemaire, Jean-Jaques, Taub, Ethan, Schüpbach, W.M. Michael, Pollo, Claudio, Guzman, Raphael, Wardell, Karin, Schkommodau, Erik, Hemm-Ode, Simone

2016, Coigny, Florian, Shah, Ashesh, Hemm-Ode, Simone, Ganz, Nicolas