Zogg, Andreas
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New scale-up technologies for multipurpose pharmaceutical production plants. Use case of a heterogeneous hydrogenation process
2023-07-06, Furrer, Thierry, Levis, Michael, Berger, Bernhard, Kandziora, Maja, Zogg, Andreas
Development of a novel measurement setup to study and predict electrostatic discharges in agitated glass‐lined vessels
2024-02-12, Brönnimann, Benedikt, Egli‐Tedesco, Daniel, Schwenzfeuer, Klaus, Zogg, Andreas
Two glass lined reactors in a launch platform facility operated by Syngenta have been damaged during the crystallization of an organic compound due to electrostatic discharges. The goal of this work was to design and commission a novel setup to measure charges and currents generated by this slurry in a laboratory‐scale reactor. An improved and more sophisticated setup was then proposed for possible implementation in Syngenta's own laboratories. With this novel setup, the electrostatic charging of stirred suspensions involving nonconductive solvents could be accurately measured in the context of a case study that involved the suspension that led to liner damages in the production facilities of Syngenta.
Modeling-based approach towards quality by design for a telescoped process
2024, Zahnd, This, Kandziora, Maja, Levis, Michael K., Zogg, Andreas
A telescoped, two-step synthesis was investigated by applying Quality by Design principles. A kinetic model consisting of 12 individual reactions was successfully established to describe the synthesis and side reactions. The resulting model predicts the effects of changes in process parameters on total yield and quality. Contour plots were created by varying process parameters and displaying the model predicted process response. The areas in which the process response fulfils predetermined quality requirements are called design spaces. New ranges for process parameters were explored within these design spaces. New conditions were found that increased the robustness of the process and allowed for a considerable reduction of the used amounts of a reagent. Further optimizations, based on the newly generated knowledge, are expected. Improvements can either be direct process improvements or enhancements to control strategies. The developed strategies can also be applied to other processes, enhancing upcoming and preexisting research and development efforts.