Modeling-based approach towards quality by design for a telescoped process
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Author (Corporation)
Publication date
2024
Typ of student thesis
Course of study
Collections
Type
01A - Journal article
Editors
Editor (Corporation)
Supervisor
Parent work
Chimia
Special issue
DOI of the original publication
Link
Series
Series number
Volume
78
Issue / Number
3
Pages / Duration
135-141
Patent number
Publisher / Publishing institution
Schweizerische Chemische Gesellschaft
Place of publication / Event location
Edition
Version
Programming language
Assignee
Practice partner / Client
Abstract
A telescoped, two-step synthesis was investigated by applying Quality by Design principles. A kinetic model consisting of 12 individual reactions was successfully established to describe the synthesis and side reactions. The resulting model predicts the effects of changes in process parameters on total yield and quality. Contour plots were created by varying process parameters and displaying the model predicted process response. The areas in which the process response fulfils predetermined quality requirements are called design spaces. New ranges for process parameters were explored within these design spaces. New conditions were found that increased the robustness of the process and allowed for a considerable reduction of the used amounts of a reagent. Further optimizations, based on the newly generated knowledge, are expected. Improvements can either be direct process improvements or enhancements to control strategies. The developed strategies can also be applied to other processes, enhancing upcoming and preexisting research and development efforts.
Keywords
Continuous process improvement, Kinetic modeling, Quality by design (QbD)
Subject (DDC)
Event
Exhibition start date
Exhibition end date
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Conference end date
Date of the last check
ISBN
ISSN
2673-2424
0009-4293
0009-4293
Language
English
Created during FHNW affiliation
Yes
Strategic action fields FHNW
Publication status
Published
Review
Peer review of the complete publication
Open access category
Diamond
License
Citation
Zahnd, T., Kandziora, M., Levis, M. K., & Zogg, A. (2024). Modeling-based approach towards quality by design for a telescoped process. Chimia, 78(3), 135–141. https://doi.org/10.2533/chimia.2024.135