2021-04-21, Hradetzky, David, Gazdhar, Amiq, Ruzgys, Paulius, Böhringer, Stephan, Sila Dokumaci, Ayse, Hari, Yvonne, Schürch, Christian, Brühl, Frido, Schürch, Stefan, Sönke, Szidat, Riether, Carsten, Satkauskas, Saulius, Geiser, Thomas

An advanced stage, centrally localized invasive tumor is a major cause of sudden death in lung cancer patients. Currently, chemotherapy, radiotherapy, laser ablation, or surgical resection if possible are the available state-of-the-art treatments but none of these guarantee remedy or long-term relief and are often associated with fatal complications. Allowing localized chemotherapy, by direct and confined drug delivery only at the tumor site, could be a promising option for preoperative down staging or palliative therapy. Here we report the localized and targeted application of intra tumor delivery of chemotherapeutics using a novel device based on the principle of electrospray.