Electrospray mediated localized and targeted chemotherapy in a mouse model of lung cancer
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Authors
Gazdhar, Amiq
Ruzgys, Paulius
Böhringer, Stephan
Sila Dokumaci, Ayse
Hari, Yvonne
Schürch, Christian
Brühl, Frido
Schürch, Stefan
Sönke, Szidat
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Publication date
21.04.2021
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01A - Journal article
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Frontiers in Pharmacology
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Section: Translational Pharmacology
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Abstract
An advanced stage, centrally localized invasive tumor is a major cause of sudden death in lung cancer patients. Currently, chemotherapy, radiotherapy, laser ablation, or surgical resection if possible are the available state-of-the-art treatments but none of these guarantee remedy or long-term relief and are often associated with fatal complications. Allowing localized chemotherapy, by direct and confined drug delivery only at the tumor site, could be a promising option for preoperative down staging or palliative therapy. Here we report the localized and targeted application of intra tumor delivery of chemotherapeutics using a novel device based on the principle of electrospray.
Keywords
Ocalized and targeted therapy, Electrospray, Novel cancer treatment, Coulomb repulsion, Localized tumor treatment
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1663-9812
Language
English
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Yes
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Published
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Peer review of the complete publication
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Gold
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Citation
Hradetzky, D., Gazdhar, A., Ruzgys, P., Böhringer, S., Sila Dokumaci, A., Hari, Y., Schürch, C., Brühl, F., Schürch, S., Sönke, S., Riether, C., Satkauskas, S., & Geiser, T. (2021). Electrospray mediated localized and targeted chemotherapy in a mouse model of lung cancer. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2021.643492