Separation of conglomerate forming enantiomers using a novel continuous preferential crystallization process
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Author (Corporation)
Publication date
07.08.2015
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01A - Journal article
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AIChE Journal
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Volume
61
Issue / Number
9
Pages / Duration
2810 - 2823
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Publisher / Publishing institution
Wiley
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Abstract
Providing enantiomerically pure products is of key importance in the fine chemicals, food, and pharmaceutical industries. A continuous preferential crystallization process is presented that allows the separation of conglomerate forming enantiomers in a stable, robust, and flexible way. This is achieved by coupling two continuous crystallizers by exchanging their clear liquid phases. Each crystallizer is connected to a suspension mill responsible for in situ seed generation through particle breakage. The dynamic and steady-state behavior of this process is extensively analyzed for racemic feed streams through process simulations, and parameter regions, which yield pure enantiomers in both crystallizers, are identified. For enriched feed streams, it is further shown when this novel flow sheet is capable of outperforming an ideal batch process in terms of solvent consumption per unit mass of desired enantiopure product produced.
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0001-1541
1547-5905
1547-5905
Language
English
Created during FHNW affiliation
No
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Published
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Peer review of the complete publication
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Green
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Citation
Vetter, T., Burcham, C. L., & Doherty, M. F. (2015). Separation of conglomerate forming enantiomers using a novel continuous preferential crystallization process. AIChE Journal, 61(9), 2810–2823. https://doi.org/10.1002/aic.14934